Validation of a pharmacological imaging challenge using (11)C-buprenorphine and (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography to study the effects of buprenorphine to the rat brain

AIM: Buprenorphine mainly acts as an agonist of mu-opioid receptors (mu-OR). High dose buprenorphine does not cause respiratory depression and can be safely administered to elicit typical opioid effects and explore pharmacodynamics. Acute buprenorphine, associated with functional and quantitative ne...

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Detalles Bibliográficos
Autores principales: Soyer, Amélie, Leterrier, Sarah, Breuil, Louise, Goislard, Maud, Leroy, Claire, Saba, Wadad, Thibault, Karine, Bo, Gregory Dal, Bottlaender, Michel, Caillé, Fabien, Goutal, Sébastien, Tournier, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205997/
https://www.ncbi.nlm.nih.gov/pubmed/37234261
http://dx.doi.org/10.3389/fnins.2023.1181786

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