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Mnemonic representations in human lateral geniculate nucleus

There is a growing appreciation for the role of the thalamus in high-level cognition. Motivated by findings that internal cognitive state drives activity in feedback layers of primary visual cortex (V1) that target the lateral geniculate nucleus (LGN), we investigated the role of LGN in working memo...

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Autores principales: Rahmati, Masih, Curtis, Clayton E., Sreenivasan, Kartik K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206025/
https://www.ncbi.nlm.nih.gov/pubmed/37234404
http://dx.doi.org/10.3389/fnbeh.2023.1094226
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author Rahmati, Masih
Curtis, Clayton E.
Sreenivasan, Kartik K.
author_facet Rahmati, Masih
Curtis, Clayton E.
Sreenivasan, Kartik K.
author_sort Rahmati, Masih
collection PubMed
description There is a growing appreciation for the role of the thalamus in high-level cognition. Motivated by findings that internal cognitive state drives activity in feedback layers of primary visual cortex (V1) that target the lateral geniculate nucleus (LGN), we investigated the role of LGN in working memory (WM). Specifically, we leveraged model-based neuroimaging approaches to test the hypothesis that human LGN encodes information about spatial locations temporarily encoded in WM. First, we localized and derived a detailed topographic organization in LGN that accords well with previous findings in humans and non-human primates. Next, we used models constructed on the spatial preferences of LGN populations in order to reconstruct spatial locations stored in WM as subjects performed modified memory-guided saccade tasks. We found that population LGN activity faithfully encoded the spatial locations held in memory in all subjects. Importantly, our tasks and models allowed us to dissociate the locations of retinal stimulation and the motor metrics of memory-guided saccades from the maintained spatial locations, thus confirming that human LGN represents true WM information. These findings add LGN to the growing list of subcortical regions involved in WM, and suggest a key pathway by which memories may influence incoming processing at the earliest levels of the visual hierarchy.
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spelling pubmed-102060252023-05-25 Mnemonic representations in human lateral geniculate nucleus Rahmati, Masih Curtis, Clayton E. Sreenivasan, Kartik K. Front Behav Neurosci Neuroscience There is a growing appreciation for the role of the thalamus in high-level cognition. Motivated by findings that internal cognitive state drives activity in feedback layers of primary visual cortex (V1) that target the lateral geniculate nucleus (LGN), we investigated the role of LGN in working memory (WM). Specifically, we leveraged model-based neuroimaging approaches to test the hypothesis that human LGN encodes information about spatial locations temporarily encoded in WM. First, we localized and derived a detailed topographic organization in LGN that accords well with previous findings in humans and non-human primates. Next, we used models constructed on the spatial preferences of LGN populations in order to reconstruct spatial locations stored in WM as subjects performed modified memory-guided saccade tasks. We found that population LGN activity faithfully encoded the spatial locations held in memory in all subjects. Importantly, our tasks and models allowed us to dissociate the locations of retinal stimulation and the motor metrics of memory-guided saccades from the maintained spatial locations, thus confirming that human LGN represents true WM information. These findings add LGN to the growing list of subcortical regions involved in WM, and suggest a key pathway by which memories may influence incoming processing at the earliest levels of the visual hierarchy. Frontiers Media S.A. 2023-05-10 /pmc/articles/PMC10206025/ /pubmed/37234404 http://dx.doi.org/10.3389/fnbeh.2023.1094226 Text en Copyright © 2023 Rahmati, Curtis and Sreenivasan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rahmati, Masih
Curtis, Clayton E.
Sreenivasan, Kartik K.
Mnemonic representations in human lateral geniculate nucleus
title Mnemonic representations in human lateral geniculate nucleus
title_full Mnemonic representations in human lateral geniculate nucleus
title_fullStr Mnemonic representations in human lateral geniculate nucleus
title_full_unstemmed Mnemonic representations in human lateral geniculate nucleus
title_short Mnemonic representations in human lateral geniculate nucleus
title_sort mnemonic representations in human lateral geniculate nucleus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206025/
https://www.ncbi.nlm.nih.gov/pubmed/37234404
http://dx.doi.org/10.3389/fnbeh.2023.1094226
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