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Pathogenicity and epidemiological survey of fowl adenovirus in Shandong Province from 2021 to 2022

In recent years, the poultry industry had been markedly affected by adenoviral diseases such as hydropericardium syndrome and inclusion body hepatitis caused by fowl adenovirus (FAdV), which have become increasingly prevalent in China. Shandong Province, China, is an important area for poultry breed...

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Autores principales: Wang, Tailong, Meng, Fanliang, Chen, Changxiu, Shen, Yesheng, Li, Peixun, Xu, Jie, Feng, Zhaoyang, Qu, Xiuchao, Wang, Fuyong, Li, Baoquan, Liu, Mengda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206033/
https://www.ncbi.nlm.nih.gov/pubmed/37234528
http://dx.doi.org/10.3389/fmicb.2023.1166078
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author Wang, Tailong
Meng, Fanliang
Chen, Changxiu
Shen, Yesheng
Li, Peixun
Xu, Jie
Feng, Zhaoyang
Qu, Xiuchao
Wang, Fuyong
Li, Baoquan
Liu, Mengda
author_facet Wang, Tailong
Meng, Fanliang
Chen, Changxiu
Shen, Yesheng
Li, Peixun
Xu, Jie
Feng, Zhaoyang
Qu, Xiuchao
Wang, Fuyong
Li, Baoquan
Liu, Mengda
author_sort Wang, Tailong
collection PubMed
description In recent years, the poultry industry had been markedly affected by adenoviral diseases such as hydropericardium syndrome and inclusion body hepatitis caused by fowl adenovirus (FAdV), which have become increasingly prevalent in China. Shandong Province, China, is an important area for poultry breeding where various complex and diverse FAdV serotypes were isolated. However, the dominant strains and their pathogenic characteristics are not yet reported. Therefore, a pathogenicity and epidemiological survey of FAdV was conducted, showing that the local dominant serotypes of FAdV epidemics were FAdV-2, FAdV-4, FAdV-8b, and FAdV-11. Their mortality rates in the 17-day-old specific-pathogen-free (SPF) chicks ranged from 10 to 80%; clinical signs included mental depression, diarrhea, and wasting. The maximum duration of viral shedding was 14 days. The highest incidence in all infected groups was on days 5–9, and then gradual regression occurred thereafter. The most pronounced symptoms occurred in chicks infected with FAdV-4, including pericardial effusion and inclusion body hepatitis lesions. Our results add to the current epidemiological data on FAdV in poultry flocks in Shandong and elucidate the pathogenicity of dominant serotypes. This information may be important for FAdV vaccine development and comprehensive epidemic prevention and control.
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spelling pubmed-102060332023-05-25 Pathogenicity and epidemiological survey of fowl adenovirus in Shandong Province from 2021 to 2022 Wang, Tailong Meng, Fanliang Chen, Changxiu Shen, Yesheng Li, Peixun Xu, Jie Feng, Zhaoyang Qu, Xiuchao Wang, Fuyong Li, Baoquan Liu, Mengda Front Microbiol Microbiology In recent years, the poultry industry had been markedly affected by adenoviral diseases such as hydropericardium syndrome and inclusion body hepatitis caused by fowl adenovirus (FAdV), which have become increasingly prevalent in China. Shandong Province, China, is an important area for poultry breeding where various complex and diverse FAdV serotypes were isolated. However, the dominant strains and their pathogenic characteristics are not yet reported. Therefore, a pathogenicity and epidemiological survey of FAdV was conducted, showing that the local dominant serotypes of FAdV epidemics were FAdV-2, FAdV-4, FAdV-8b, and FAdV-11. Their mortality rates in the 17-day-old specific-pathogen-free (SPF) chicks ranged from 10 to 80%; clinical signs included mental depression, diarrhea, and wasting. The maximum duration of viral shedding was 14 days. The highest incidence in all infected groups was on days 5–9, and then gradual regression occurred thereafter. The most pronounced symptoms occurred in chicks infected with FAdV-4, including pericardial effusion and inclusion body hepatitis lesions. Our results add to the current epidemiological data on FAdV in poultry flocks in Shandong and elucidate the pathogenicity of dominant serotypes. This information may be important for FAdV vaccine development and comprehensive epidemic prevention and control. Frontiers Media S.A. 2023-05-10 /pmc/articles/PMC10206033/ /pubmed/37234528 http://dx.doi.org/10.3389/fmicb.2023.1166078 Text en Copyright © 2023 Wang, Meng, Chen, Shen, Li, Xu, Feng, Qu, Wang, Li and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Tailong
Meng, Fanliang
Chen, Changxiu
Shen, Yesheng
Li, Peixun
Xu, Jie
Feng, Zhaoyang
Qu, Xiuchao
Wang, Fuyong
Li, Baoquan
Liu, Mengda
Pathogenicity and epidemiological survey of fowl adenovirus in Shandong Province from 2021 to 2022
title Pathogenicity and epidemiological survey of fowl adenovirus in Shandong Province from 2021 to 2022
title_full Pathogenicity and epidemiological survey of fowl adenovirus in Shandong Province from 2021 to 2022
title_fullStr Pathogenicity and epidemiological survey of fowl adenovirus in Shandong Province from 2021 to 2022
title_full_unstemmed Pathogenicity and epidemiological survey of fowl adenovirus in Shandong Province from 2021 to 2022
title_short Pathogenicity and epidemiological survey of fowl adenovirus in Shandong Province from 2021 to 2022
title_sort pathogenicity and epidemiological survey of fowl adenovirus in shandong province from 2021 to 2022
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206033/
https://www.ncbi.nlm.nih.gov/pubmed/37234528
http://dx.doi.org/10.3389/fmicb.2023.1166078
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