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Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development

INTRODUCTION: Quality of life (QoL) outcomes in patients undergoing radical cystectomy (RC) with orthotopic neobladder (ONB) or ileal conduit (IC) have been extensively investigated. However, a general lack of consensus on QoL’s predictive factors exists. The aim of the study was to develop a nomogr...

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Autores principales: Siracusano, Salvatore, Zaka, Agustina, Zaffuto, Emanuele, Porcaro, Antonio Benito, Colombo, Renzo, Talamini, Renato, Romantini, Federico, Montorsi, Francesco, Lonardi, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206116/
https://www.ncbi.nlm.nih.gov/pubmed/37234982
http://dx.doi.org/10.3389/fonc.2023.1055140
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author Siracusano, Salvatore
Zaka, Agustina
Zaffuto, Emanuele
Porcaro, Antonio Benito
Colombo, Renzo
Talamini, Renato
Romantini, Federico
Montorsi, Francesco
Lonardi, Cristina
author_facet Siracusano, Salvatore
Zaka, Agustina
Zaffuto, Emanuele
Porcaro, Antonio Benito
Colombo, Renzo
Talamini, Renato
Romantini, Federico
Montorsi, Francesco
Lonardi, Cristina
author_sort Siracusano, Salvatore
collection PubMed
description INTRODUCTION: Quality of life (QoL) outcomes in patients undergoing radical cystectomy (RC) with orthotopic neobladder (ONB) or ileal conduit (IC) have been extensively investigated. However, a general lack of consensus on QoL’s predictive factors exists. The aim of the study was to develop a nomogram using preoperative parameters to predict global QoL outcome in patients with localized muscle-invasive bladder cancer (MIBC) undergoing RC with ONB or IC urinary diversion (UD). METHODS: A cohort of 319 patients who underwent RC and ONB or IC were retrospectively enrolled. Multivariable linear regression analyses were used to predict the global QoL score of the European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30), according to the patient characteristics and UD. A nomogram was developed and internally validated. RESULTS: Patients’ data in the two study groups significantly differed with regard to comorbidity profiles (chronic cardiac failure, p < 0.001; chronic kidney disease, p < 0.01; hypertension, p < 0.03; diabetic disease, p = 0.02; chronic arthritis, p = 0.02). A multivariable model that included patient age at surgery, UD, chronic cardiac disease, and peripheral vascular disease represented the basis for the nomogram. The calibration plot of the prediction model showed a systematic overestimation of the predicted global QoL score over the observed scores, with a slight underestimation for observed global QoL scores between 57 and 72. After performing leave-one-out cross-validation, the root mean square error (RMSE) emerged as 24.0. DISCUSSION/CONCLUSION: A novel nomogram based completely on known preoperative factors was developed for patients with MIBC undergoing RC to predict a mid-term QoL outcome.
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spelling pubmed-102061162023-05-25 Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development Siracusano, Salvatore Zaka, Agustina Zaffuto, Emanuele Porcaro, Antonio Benito Colombo, Renzo Talamini, Renato Romantini, Federico Montorsi, Francesco Lonardi, Cristina Front Oncol Oncology INTRODUCTION: Quality of life (QoL) outcomes in patients undergoing radical cystectomy (RC) with orthotopic neobladder (ONB) or ileal conduit (IC) have been extensively investigated. However, a general lack of consensus on QoL’s predictive factors exists. The aim of the study was to develop a nomogram using preoperative parameters to predict global QoL outcome in patients with localized muscle-invasive bladder cancer (MIBC) undergoing RC with ONB or IC urinary diversion (UD). METHODS: A cohort of 319 patients who underwent RC and ONB or IC were retrospectively enrolled. Multivariable linear regression analyses were used to predict the global QoL score of the European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30), according to the patient characteristics and UD. A nomogram was developed and internally validated. RESULTS: Patients’ data in the two study groups significantly differed with regard to comorbidity profiles (chronic cardiac failure, p < 0.001; chronic kidney disease, p < 0.01; hypertension, p < 0.03; diabetic disease, p = 0.02; chronic arthritis, p = 0.02). A multivariable model that included patient age at surgery, UD, chronic cardiac disease, and peripheral vascular disease represented the basis for the nomogram. The calibration plot of the prediction model showed a systematic overestimation of the predicted global QoL score over the observed scores, with a slight underestimation for observed global QoL scores between 57 and 72. After performing leave-one-out cross-validation, the root mean square error (RMSE) emerged as 24.0. DISCUSSION/CONCLUSION: A novel nomogram based completely on known preoperative factors was developed for patients with MIBC undergoing RC to predict a mid-term QoL outcome. Frontiers Media S.A. 2023-05-10 /pmc/articles/PMC10206116/ /pubmed/37234982 http://dx.doi.org/10.3389/fonc.2023.1055140 Text en Copyright © 2023 Siracusano, Zaka, Zaffuto, Porcaro, Colombo, Talamini, Romantini, Montorsi and Lonardi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Siracusano, Salvatore
Zaka, Agustina
Zaffuto, Emanuele
Porcaro, Antonio Benito
Colombo, Renzo
Talamini, Renato
Romantini, Federico
Montorsi, Francesco
Lonardi, Cristina
Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development
title Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development
title_full Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development
title_fullStr Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development
title_full_unstemmed Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development
title_short Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development
title_sort predicting global qol after orthotopic neobladder or ileal conduit diversion: nomogram development
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206116/
https://www.ncbi.nlm.nih.gov/pubmed/37234982
http://dx.doi.org/10.3389/fonc.2023.1055140
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