Ant venoms contain vertebrate-selective pain-causing sodium channel toxins

Stings of certain ant species (Hymenoptera: Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms are venom peptides that modulate the activity of voltage-gated sodium (Na(V)) channels, reducing their voltage threshold for activation and...

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Autores principales: Robinson, Samuel D., Deuis, Jennifer R., Touchard, Axel, Keramidas, Angelo, Mueller, Alexander, Schroeder, Christina I., Barassé, Valentine, Walker, Andrew A., Brinkwirth, Nina, Jami, Sina, Bonnafé, Elsa, Treilhou, Michel, Undheim, Eivind A. B., Schmidt, Justin O., King, Glenn F., Vetter, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206162/
https://www.ncbi.nlm.nih.gov/pubmed/37221205
http://dx.doi.org/10.1038/s41467-023-38839-1
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author Robinson, Samuel D.
Deuis, Jennifer R.
Touchard, Axel
Keramidas, Angelo
Mueller, Alexander
Schroeder, Christina I.
Barassé, Valentine
Walker, Andrew A.
Brinkwirth, Nina
Jami, Sina
Bonnafé, Elsa
Treilhou, Michel
Undheim, Eivind A. B.
Schmidt, Justin O.
King, Glenn F.
Vetter, Irina
author_facet Robinson, Samuel D.
Deuis, Jennifer R.
Touchard, Axel
Keramidas, Angelo
Mueller, Alexander
Schroeder, Christina I.
Barassé, Valentine
Walker, Andrew A.
Brinkwirth, Nina
Jami, Sina
Bonnafé, Elsa
Treilhou, Michel
Undheim, Eivind A. B.
Schmidt, Justin O.
King, Glenn F.
Vetter, Irina
author_sort Robinson, Samuel D.
collection PubMed
description Stings of certain ant species (Hymenoptera: Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms are venom peptides that modulate the activity of voltage-gated sodium (Na(V)) channels, reducing their voltage threshold for activation and inhibiting channel inactivation. These peptide toxins are likely vertebrate-selective, consistent with a primarily defensive function. They emerged early in the Formicidae lineage and may have been a pivotal factor in the expansion of ants.
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spelling pubmed-102061622023-05-25 Ant venoms contain vertebrate-selective pain-causing sodium channel toxins Robinson, Samuel D. Deuis, Jennifer R. Touchard, Axel Keramidas, Angelo Mueller, Alexander Schroeder, Christina I. Barassé, Valentine Walker, Andrew A. Brinkwirth, Nina Jami, Sina Bonnafé, Elsa Treilhou, Michel Undheim, Eivind A. B. Schmidt, Justin O. King, Glenn F. Vetter, Irina Nat Commun Article Stings of certain ant species (Hymenoptera: Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms are venom peptides that modulate the activity of voltage-gated sodium (Na(V)) channels, reducing their voltage threshold for activation and inhibiting channel inactivation. These peptide toxins are likely vertebrate-selective, consistent with a primarily defensive function. They emerged early in the Formicidae lineage and may have been a pivotal factor in the expansion of ants. Nature Publishing Group UK 2023-05-23 /pmc/articles/PMC10206162/ /pubmed/37221205 http://dx.doi.org/10.1038/s41467-023-38839-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Robinson, Samuel D.
Deuis, Jennifer R.
Touchard, Axel
Keramidas, Angelo
Mueller, Alexander
Schroeder, Christina I.
Barassé, Valentine
Walker, Andrew A.
Brinkwirth, Nina
Jami, Sina
Bonnafé, Elsa
Treilhou, Michel
Undheim, Eivind A. B.
Schmidt, Justin O.
King, Glenn F.
Vetter, Irina
Ant venoms contain vertebrate-selective pain-causing sodium channel toxins
title Ant venoms contain vertebrate-selective pain-causing sodium channel toxins
title_full Ant venoms contain vertebrate-selective pain-causing sodium channel toxins
title_fullStr Ant venoms contain vertebrate-selective pain-causing sodium channel toxins
title_full_unstemmed Ant venoms contain vertebrate-selective pain-causing sodium channel toxins
title_short Ant venoms contain vertebrate-selective pain-causing sodium channel toxins
title_sort ant venoms contain vertebrate-selective pain-causing sodium channel toxins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206162/
https://www.ncbi.nlm.nih.gov/pubmed/37221205
http://dx.doi.org/10.1038/s41467-023-38839-1
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