Nanobody inhibitors of Plexin-B1 identify allostery in plexin–semaphorin interactions and signaling

Plexin-B1 is a receptor for the cell surface semaphorin, Sema4D. This signaling system has been implicated in a variety of human diseases, including cancer, multiple sclerosis and osteoporosis. While inhibitors of the Plexin-B1:Sema4D interaction have been previously reported, understanding their me...

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Detalles Bibliográficos
Autores principales: Cowan, Richard, Trokter, Martina, Oleksy, Arkadiusz, Fedorova, Marina, Sawmynaden, Kovilen, Worzfeld, Thomas, Offermanns, Stefan, Matthews, David, Carr, Mark D., Hall, Gareth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206189/
https://www.ncbi.nlm.nih.gov/pubmed/37088134
http://dx.doi.org/10.1016/j.jbc.2023.104740

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