Dual inhibition of phosphoinositide 3-kinases delta and gamma reduces chronic B cell activation and autoantibody production in a mouse model of lupus

Phosphoinositide 3-kinase delta (PI3Kδ) plays key roles in normal B cell activation and is chronically activated in malignant B cells. Targeting of PI3Kδ using FDA-approved drugs Idelalisib or Umbralisib has shown efficacy in treatment of multiple B cell malignancies. Duvelisib, an inhibitor targeti...

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Detalles Bibliográficos
Autores principales: Olayinka-Adefemi, Folayemi, Hou, Sen, Marshall, Aaron J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206234/
https://www.ncbi.nlm.nih.gov/pubmed/37234154
http://dx.doi.org/10.3389/fimmu.2023.1115244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206234/
https://www.ncbi.nlm.nih.gov/pubmed/37234154
http://dx.doi.org/10.3389/fimmu.2023.1115244

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