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COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study

BACKGROUND: Emerging evidence suggested that coronavirus disease 2019 (COVID-19) patients were more prone to acute skeletal muscle loss and suffer sequelae, including weakness, arthromyalgia, depression and anxiety. Meanwhile, it was observed that sarcopenia (SP) was associated with susceptibility,...

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Autores principales: Liu, Chao, Liu, Ningyuan, Zeng, Yi, Xiao, Bo, Wang, Pingxiao, Zhou, Chuqiao, Xia, Yu, Zhao, Ziyue, Xiao, Tao, Li, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206246/
https://www.ncbi.nlm.nih.gov/pubmed/37234804
http://dx.doi.org/10.3389/fendo.2023.1162936
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author Liu, Chao
Liu, Ningyuan
Zeng, Yi
Xiao, Bo
Wang, Pingxiao
Zhou, Chuqiao
Xia, Yu
Zhao, Ziyue
Xiao, Tao
Li, Hui
author_facet Liu, Chao
Liu, Ningyuan
Zeng, Yi
Xiao, Bo
Wang, Pingxiao
Zhou, Chuqiao
Xia, Yu
Zhao, Ziyue
Xiao, Tao
Li, Hui
author_sort Liu, Chao
collection PubMed
description BACKGROUND: Emerging evidence suggested that coronavirus disease 2019 (COVID-19) patients were more prone to acute skeletal muscle loss and suffer sequelae, including weakness, arthromyalgia, depression and anxiety. Meanwhile, it was observed that sarcopenia (SP) was associated with susceptibility, hospitalization and severity of COVID-19. However, it is not known whether there is causal relationship between COVID‐19 and SP-related traits. Mendelian randomization (MR) was a valid method for inferring causality. METHODS: Data was extracted from the COVID‐19 Host Genetic Initiative and the UK Biobank without sample overlapping. The MR analysis was performed with inverse variance weighted, weighted median, MR-Egger, RAPS and CAUSE, MR-APSS. Sensitivity analysis was conducted with MR-Egger intercept test, Cochran’s Q test, MR-PRESSO to eliminate pleiotropy. RESULTS: There was insufficient result in the MR-APSS method to support a direct causal relationship after the Bonferroni correction. Most other MR results were also nominally consistent with the MR-APSS result. CONCLUSIONS: Our study first explored the causal relationship between COVID-19 and SP-related traits, but the result indicated that they may indirectly interact with each other. We highlighted that older people had better absorb enough nutrition and strengthen exercise to directly cope with SP during the COVID-19 pandemic.
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spelling pubmed-102062462023-05-25 COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study Liu, Chao Liu, Ningyuan Zeng, Yi Xiao, Bo Wang, Pingxiao Zhou, Chuqiao Xia, Yu Zhao, Ziyue Xiao, Tao Li, Hui Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Emerging evidence suggested that coronavirus disease 2019 (COVID-19) patients were more prone to acute skeletal muscle loss and suffer sequelae, including weakness, arthromyalgia, depression and anxiety. Meanwhile, it was observed that sarcopenia (SP) was associated with susceptibility, hospitalization and severity of COVID-19. However, it is not known whether there is causal relationship between COVID‐19 and SP-related traits. Mendelian randomization (MR) was a valid method for inferring causality. METHODS: Data was extracted from the COVID‐19 Host Genetic Initiative and the UK Biobank without sample overlapping. The MR analysis was performed with inverse variance weighted, weighted median, MR-Egger, RAPS and CAUSE, MR-APSS. Sensitivity analysis was conducted with MR-Egger intercept test, Cochran’s Q test, MR-PRESSO to eliminate pleiotropy. RESULTS: There was insufficient result in the MR-APSS method to support a direct causal relationship after the Bonferroni correction. Most other MR results were also nominally consistent with the MR-APSS result. CONCLUSIONS: Our study first explored the causal relationship between COVID-19 and SP-related traits, but the result indicated that they may indirectly interact with each other. We highlighted that older people had better absorb enough nutrition and strengthen exercise to directly cope with SP during the COVID-19 pandemic. Frontiers Media S.A. 2023-05-10 /pmc/articles/PMC10206246/ /pubmed/37234804 http://dx.doi.org/10.3389/fendo.2023.1162936 Text en Copyright © 2023 Liu, Liu, Zeng, Xiao, Wang, Zhou, Xia, Zhao, Xiao and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Liu, Chao
Liu, Ningyuan
Zeng, Yi
Xiao, Bo
Wang, Pingxiao
Zhou, Chuqiao
Xia, Yu
Zhao, Ziyue
Xiao, Tao
Li, Hui
COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study
title COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study
title_full COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study
title_fullStr COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study
title_full_unstemmed COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study
title_short COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study
title_sort covid‐19 and sarcopenia-related traits: a bidirectional mendelian randomization study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206246/
https://www.ncbi.nlm.nih.gov/pubmed/37234804
http://dx.doi.org/10.3389/fendo.2023.1162936
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