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Mapping metabolite change in the mouse brain after esketamine injection by ambient mass spectrometry imaging and metabolomics

Ketamine is a new, fast, and effective antidepression treatment method; however, the possible dissociation effects, sensory changes, abuse risk, and the inability to accurately identify whether patients have a significant response to ketamine limit its clinical use. Further exploration of the antide...

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Autores principales: Liu, Guan-Xi, Li, Ze-Lin, Lin, Su-Yan, Wang, Qian, Luo, Zheng-Yi, Wu, Kai, Zhou, Yan-Lin, Ning, Yu-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206402/
https://www.ncbi.nlm.nih.gov/pubmed/37234214
http://dx.doi.org/10.3389/fpsyt.2023.1109344
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author Liu, Guan-Xi
Li, Ze-Lin
Lin, Su-Yan
Wang, Qian
Luo, Zheng-Yi
Wu, Kai
Zhou, Yan-Lin
Ning, Yu-Ping
author_facet Liu, Guan-Xi
Li, Ze-Lin
Lin, Su-Yan
Wang, Qian
Luo, Zheng-Yi
Wu, Kai
Zhou, Yan-Lin
Ning, Yu-Ping
author_sort Liu, Guan-Xi
collection PubMed
description Ketamine is a new, fast, and effective antidepression treatment method; however, the possible dissociation effects, sensory changes, abuse risk, and the inability to accurately identify whether patients have a significant response to ketamine limit its clinical use. Further exploration of the antidepressant mechanisms of ketamine will contribute to its safe and practical application. Metabolites, the products of upstream gene expression and protein regulatory networks, play an essential role in various physiological and pathophysiological processes. In traditional metabonomics it is difficult to achieve the spatial localization of metabolites, which limits the further analysis of brain metabonomics by researchers. Here, we used a metabolic network mapping method called ambient air flow-assisted desorption electrospray ionization (AFADESI)-mass spectrometry imaging (MSI). We found the main changes in glycerophospholipid metabolism around the brain and sphingolipid metabolism changed mainly in the globus pallidus, which showed the most significant metabolite change after esketamine injection. The spatial distribution of metabolic changes was evaluated in the whole brain, and the potential mechanism of esketamine’s antidepressant effect was explored in this research.
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spelling pubmed-102064022023-05-25 Mapping metabolite change in the mouse brain after esketamine injection by ambient mass spectrometry imaging and metabolomics Liu, Guan-Xi Li, Ze-Lin Lin, Su-Yan Wang, Qian Luo, Zheng-Yi Wu, Kai Zhou, Yan-Lin Ning, Yu-Ping Front Psychiatry Psychiatry Ketamine is a new, fast, and effective antidepression treatment method; however, the possible dissociation effects, sensory changes, abuse risk, and the inability to accurately identify whether patients have a significant response to ketamine limit its clinical use. Further exploration of the antidepressant mechanisms of ketamine will contribute to its safe and practical application. Metabolites, the products of upstream gene expression and protein regulatory networks, play an essential role in various physiological and pathophysiological processes. In traditional metabonomics it is difficult to achieve the spatial localization of metabolites, which limits the further analysis of brain metabonomics by researchers. Here, we used a metabolic network mapping method called ambient air flow-assisted desorption electrospray ionization (AFADESI)-mass spectrometry imaging (MSI). We found the main changes in glycerophospholipid metabolism around the brain and sphingolipid metabolism changed mainly in the globus pallidus, which showed the most significant metabolite change after esketamine injection. The spatial distribution of metabolic changes was evaluated in the whole brain, and the potential mechanism of esketamine’s antidepressant effect was explored in this research. Frontiers Media S.A. 2023-05-10 /pmc/articles/PMC10206402/ /pubmed/37234214 http://dx.doi.org/10.3389/fpsyt.2023.1109344 Text en Copyright © 2023 Liu, Li, Lin, Wang, Luo, Wu, Zhou and Ning. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Liu, Guan-Xi
Li, Ze-Lin
Lin, Su-Yan
Wang, Qian
Luo, Zheng-Yi
Wu, Kai
Zhou, Yan-Lin
Ning, Yu-Ping
Mapping metabolite change in the mouse brain after esketamine injection by ambient mass spectrometry imaging and metabolomics
title Mapping metabolite change in the mouse brain after esketamine injection by ambient mass spectrometry imaging and metabolomics
title_full Mapping metabolite change in the mouse brain after esketamine injection by ambient mass spectrometry imaging and metabolomics
title_fullStr Mapping metabolite change in the mouse brain after esketamine injection by ambient mass spectrometry imaging and metabolomics
title_full_unstemmed Mapping metabolite change in the mouse brain after esketamine injection by ambient mass spectrometry imaging and metabolomics
title_short Mapping metabolite change in the mouse brain after esketamine injection by ambient mass spectrometry imaging and metabolomics
title_sort mapping metabolite change in the mouse brain after esketamine injection by ambient mass spectrometry imaging and metabolomics
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206402/
https://www.ncbi.nlm.nih.gov/pubmed/37234214
http://dx.doi.org/10.3389/fpsyt.2023.1109344
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