A transcriptomic intratumour heterogeneity-free signature overcomes sampling bias in prognostic risk classification for hepatocellular carcinoma

BACKGROUND & AIMS: Intratumour heterogeneity (ITH) fosters the vulnerability of RNA expression-based biomarkers derived from a single biopsy to tumour sampling bias, and is regarded as an unaddressed confounding factor for patient precision stratification using molecular biomarkers. This study a...

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Detalles Bibliográficos
Autores principales: Luo, Shangyi, Jia, Ying, Zhang, Yajing, Zhang, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206488/
https://www.ncbi.nlm.nih.gov/pubmed/37234275
http://dx.doi.org/10.1016/j.jhepr.2023.100754

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