Cargando…

Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through an ROS-dependent mechanism

Mitochondria produce reactive oxygen species (ROS), which function in signal transduction. Mitochondrial dynamics, encompassing morphological shifts between fission and fusion, can directly impact ROS levels in cancer cells. In this study, we identified an ROS-dependent mechanism for how enhanced mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Humphries, Brock A., Zhang, Anne, Buschhaus, Johanna M., Bevoor, Avinash, Farfel, Alex, Rajendran, Shrila, Cutter, Alyssa C., Luker, Gary D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206500/ https://www.ncbi.nlm.nih.gov/pubmed/37235049 http://dx.doi.org/10.1016/j.isci.2023.106788

Ejemplares similares

Targeting Disseminated Estrogen-Receptor-Positive Breast Cancer Cells in Bone Marrow
por: Buschhaus, Johanna M., et al.
Publicado: (2020)

Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer
por: Humphries, Brock A., et al.
Publicado: (2020)

Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells
por: Eckley, Samantha S., et al.
Publicado: (2019)

A Caspase-3 Reporter for Fluorescence Lifetime Imaging of Single-Cell Apoptosis
por: Buschhaus, Johanna M., et al.
Publicado: (2018)

Multiparametric MRI to quantify disease and treatment response in mice with myeloproliferative neoplasms
por: Robison, Tanner H., et al.
Publicado: (2022)

ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine
por: Hu, Jinjiao, et al.
Publicado: (2019)

Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling
por: Shahi Thakuri, Pradip, et al.
Publicado: (2020)

Enhanced Bone Metastases in Skeletally Immature Mice
por: Haley, Henry R., et al.
Publicado: (2018)

The Impact of Mitochondrial Fission-Stimulated ROS Production on Pro-Apoptotic Chemotherapy
por: Ježek, Jan, et al.
Publicado: (2021)

Mitochondrial ROS1 Increases Mitochondrial Fission and Respiration in Oral Squamous Cancer Carcinoma
por: Chang, Yu-Jung, et al.
Publicado: (2020)

Propofol induces ROS-mediated intrinsic apoptosis and migration in triple-negative breast cancer cells
por: Wang, Hao, et al.
Publicado: (2020)

Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS
por: Wang, Lixiang, et al.
Publicado: (2021)

Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy
por: Jiang, Ying, et al.
Publicado: (2022)

Deferoxamine Enhanced Mitochondrial Iron Accumulation and Promoted Cell Migration in Triple-Negative MDA-MB-231 Breast Cancer Cells Via a ROS-Dependent Mechanism
por: Chen, Chunli, et al.
Publicado: (2019)

C-Peptide Activates AMPKα and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes
por: Bhatt, Mahendra Prasad, et al.
Publicado: (2013)

Mitochondrial fission factor (MFF) frameshift variant in Bullmastiffs with mitochondrial fission encephalopathy
por: Christen, Matthias, et al.
Publicado: (2022)

Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS–mitochondrial fission–mitophagy axis
por: Liu, Ming, et al.
Publicado: (2021)

Targeting Triple-Negative Breast Cancer by the Phytopolyphenol Carnosol: ROS-Dependent Mechanisms
por: Alsamri, Halima, et al.
Publicado: (2023)

Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis
por: Shen, Li-wen, et al.
Publicado: (2021)

IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission
por: Li, Pantong, et al.
Publicado: (2019)

Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss
por: Fu, Panfeng, et al.
Publicado: (2021)

Coronary Endothelium No-Reflow Injury Is Associated with ROS-Modified Mitochondrial Fission through the JNK-Drp1 Signaling Pathway
por: Chen, Yi, et al.
Publicado: (2021)

ROS-responsive Galactosylated-nanoparticles with Doxorubicin Entrapment for Triple Negative Breast Cancer Therapy
por: Zhou, Jingyi, et al.
Publicado: (2023)

Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells
por: An, Haein, et al.
Publicado: (2021)

The effect of mechanosensitive channel MscL expression in cancer cells on 3D confined migration
por: Heureaux-Torres, Johanna, et al.
Publicado: (2018)

Annurca apple polyphenol extract promotes mesenchymal-to-epithelial transition and inhibits migration in triple-negative breast cancer cells through ROS/JNK signaling
por: Vuoso, Daniela Cristina, et al.
Publicado: (2020)

Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan
por: Lefevre, Sophie D, et al.
Publicado: (2015)

Hypoxia-dependent mitochondrial fission regulates endothelial progenitor cell migration, invasion, and tube formation
por: Kim, Da Yeon, et al.
Publicado: (2018)

DnmA and FisA Mediate Mitochondria and Peroxisome Fission, and Regulate Mitochondrial Function, ROS Production and Development in Aspergillus nidulans
por: Garrido-Bazán, Verónica, et al.
Publicado: (2020)

Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation
por: Tanwar, Jyoti, et al.
Publicado: (2022)

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission
por: O'Mealey, Gary B., et al.
Publicado: (2016)

Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator
por: Chen, Yu-Chih, et al.
Publicado: (2018)

Participation of mitochondrial fission during mitophagy
por: Mao, Kai, et al.
Publicado: (2013)

Mitochondrial Fission: Regulation and ER Connection
por: Lee, Hakjoo, et al.
Publicado: (2014)

OPA1’s shortcut to mitochondrial fission
por: Short, Ben
Publicado: (2014)

Mechanical force induces mitochondrial fission
por: Helle, Sebastian Carsten Johannes, et al.
Publicado: (2017)

Geometric instability catalyzes mitochondrial fission
por: Irajizad, Ehsan, et al.
Publicado: (2019)

Mitochondrial fission and stemness in prostate cancer
por: Civenni, Gianluca, et al.
Publicado: (2019)

Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis
por: Sênos Demarco, Rafael, et al.
Publicado: (2019)

Carnosol Induces ROS-Mediated Beclin1-Independent Autophagy and Apoptosis in Triple Negative Breast Cancer
por: Al Dhaheri, Yusra, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_scb45pgf87kls65jef2tg06id6