HRD1 promotes non-small cell lung carcinoma metastasis by blocking autophagy-mediated MIEN1 degradation

Dysregulation of autophagy has been implicated in the development of many diseases, including cancer. Here, we revealed a novel function of the E3 ubiquitin ligase HRD1 in non-small cell lung carcinoma (NSCLC) metastasis by regulating autophagy. Mechanistically, HRD1 inhibits autophagy by promoting...

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Detalles Bibliográficos
Autores principales: Zeng, Cheng, Guo, Jing, Wu, Jiajia, Che, Tiantian, Huang, Xiaoping, Liu, Huawen, Lin, Zhenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206817/
https://www.ncbi.nlm.nih.gov/pubmed/37075843
http://dx.doi.org/10.1016/j.jbc.2023.104723

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