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Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction

OBJECTIVES: Fetal human cytomegalovirus (HCMV) infection might be involved in fetal growth restriction (FGR). Maternal serostatus and the prevalence of congenital HCMV infection are affected by various factors, such as socioeconomic status and ethnicity. Therefore, the prevalence of congenital HCMV-...

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Autores principales: Funato, Yusuke, Higashimoto, Yuki, Kawamura, Yoshiki, Sakabe, Yoshiko, Iwakura, Minori, Ihira, Masaru, Shiogama, Kazuya, Miyata, Masafumi, Nishizawa, Haruki, Sekiya, Takao, Fujii, Takuma, Kosugi, Isao, Yoshikawa, Tetsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fujita Medical Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206905/
https://www.ncbi.nlm.nih.gov/pubmed/37234388
http://dx.doi.org/10.20407/fmj.2022-001
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author Funato, Yusuke
Higashimoto, Yuki
Kawamura, Yoshiki
Sakabe, Yoshiko
Iwakura, Minori
Ihira, Masaru
Shiogama, Kazuya
Miyata, Masafumi
Nishizawa, Haruki
Sekiya, Takao
Fujii, Takuma
Kosugi, Isao
Yoshikawa, Tetsushi
author_facet Funato, Yusuke
Higashimoto, Yuki
Kawamura, Yoshiki
Sakabe, Yoshiko
Iwakura, Minori
Ihira, Masaru
Shiogama, Kazuya
Miyata, Masafumi
Nishizawa, Haruki
Sekiya, Takao
Fujii, Takuma
Kosugi, Isao
Yoshikawa, Tetsushi
author_sort Funato, Yusuke
collection PubMed
description OBJECTIVES: Fetal human cytomegalovirus (HCMV) infection might be involved in fetal growth restriction (FGR). Maternal serostatus and the prevalence of congenital HCMV infection are affected by various factors, such as socioeconomic status and ethnicity. Therefore, the prevalence of congenital HCMV-related FGR should be examined in each region. METHODS: Seventy-eight cases of FGR with delivery between January 2012 and January 2017 at Fujita Health University Hospital were studied. Twenty-one non-FGR cases were also included as a control group. Placental sections obtained from the FGR and control cases were immunostained with two primary antibodies for detecting immediate early antigens. RESULTS: Nineteen placental samples from FGR cases with another etiology were excluded. Finally, 59 placental samples from FGR cases of unknown etiology were included in the pathological analysis. Four of 59 (6.8%) placental samples were positive for HCMV antigen. All four positive cases were stained with the M0854 antibody, and there were no positive case with the MAB810R antibody. Neither maternal nor infantile clinical features were different between the HCMV-positive and -negative FGR cases. A pathological examination showed a hematoma in three of four cases and infarction in two of four cases. CONCLUSIONS: HCMV antigen was detected in 6.8% of placental samples obtained from FGR cases without an obvious etiology. No remarkable maternal or neonatal clinical features discriminated HCMV-related FGR from FGR due to other causes. Vasculitis and inflammation might play important roles in the pathogenesis of HCMV-related FGR.
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spelling pubmed-102069052023-05-25 Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction Funato, Yusuke Higashimoto, Yuki Kawamura, Yoshiki Sakabe, Yoshiko Iwakura, Minori Ihira, Masaru Shiogama, Kazuya Miyata, Masafumi Nishizawa, Haruki Sekiya, Takao Fujii, Takuma Kosugi, Isao Yoshikawa, Tetsushi Fujita Med J Original Article OBJECTIVES: Fetal human cytomegalovirus (HCMV) infection might be involved in fetal growth restriction (FGR). Maternal serostatus and the prevalence of congenital HCMV infection are affected by various factors, such as socioeconomic status and ethnicity. Therefore, the prevalence of congenital HCMV-related FGR should be examined in each region. METHODS: Seventy-eight cases of FGR with delivery between January 2012 and January 2017 at Fujita Health University Hospital were studied. Twenty-one non-FGR cases were also included as a control group. Placental sections obtained from the FGR and control cases were immunostained with two primary antibodies for detecting immediate early antigens. RESULTS: Nineteen placental samples from FGR cases with another etiology were excluded. Finally, 59 placental samples from FGR cases of unknown etiology were included in the pathological analysis. Four of 59 (6.8%) placental samples were positive for HCMV antigen. All four positive cases were stained with the M0854 antibody, and there were no positive case with the MAB810R antibody. Neither maternal nor infantile clinical features were different between the HCMV-positive and -negative FGR cases. A pathological examination showed a hematoma in three of four cases and infarction in two of four cases. CONCLUSIONS: HCMV antigen was detected in 6.8% of placental samples obtained from FGR cases without an obvious etiology. No remarkable maternal or neonatal clinical features discriminated HCMV-related FGR from FGR due to other causes. Vasculitis and inflammation might play important roles in the pathogenesis of HCMV-related FGR. Fujita Medical Society 2023-05 2022-07-22 /pmc/articles/PMC10206905/ /pubmed/37234388 http://dx.doi.org/10.20407/fmj.2022-001 Text en https://creativecommons.org/licenses/by/4.0/This is an Open access article distributed under the Terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Funato, Yusuke
Higashimoto, Yuki
Kawamura, Yoshiki
Sakabe, Yoshiko
Iwakura, Minori
Ihira, Masaru
Shiogama, Kazuya
Miyata, Masafumi
Nishizawa, Haruki
Sekiya, Takao
Fujii, Takuma
Kosugi, Isao
Yoshikawa, Tetsushi
Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction
title Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction
title_full Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction
title_fullStr Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction
title_full_unstemmed Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction
title_short Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction
title_sort retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206905/
https://www.ncbi.nlm.nih.gov/pubmed/37234388
http://dx.doi.org/10.20407/fmj.2022-001
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