Temporal relation of disease onsets in patients with acute myocardial infarction and atrial fibrillation - results from a nationwide registry study

FUNDING ACKNOWLEDGEMENTS: Type of funding sources: Public hospital(s). Main funding source(s): Helsinki and Uusimaa Hospital District TYH2019309 and The Finnish Foundation for Cardiovascular Research BACKGROUND/INTRODUCTION: Acute myocardial infarction (AMI) and atrial fibrillation (AF) are commonly seen in a same patient. It is not unusual that patients are diagnosed with new-onset AF as a complication of AMI. Nevertheless, little is known about the temporal relations of these two diagnoses. PURPOSE: We evaluated the temporal relations of AMI and new-onset AF in the Nationwide Finnish Anticoagulation in Atrial Fibrillation (FinACAF) comprising all patients with AF during 2004-2018 in Finland. METHODS: Patients with AF and AMI in Finland during 2010 to 2017 were analyzed, and individual patient data from the different registries were merged. RESULTS: Of the 157,658 patients with new-onset AF, a total of 16,971 (10.8%) patients were diagnosed with AMI at any point. The mean-age was 77.5 years (SD 10.6) and 72.3 years (SD 13.2), and the proportion of females 7,864 (46.3%) and 70,873 (50.4%) in AF patients with and without AMI, respectively. Altogether 8,889 (52.4%) of the AMI-AF patients had a history of established AMI diagnosis; whereas 4,278 (25.2%) were diagnosed with AMI during the same hospitalization period as new-onset AF or within 30 days; and 3,804 (22.4%) over 30 days after new-onset AF. A total of 6,928 (40.83%) of all AMI diagnoses were diagnosed within 1 year from new-onset AF. The temporal relation between new-onset AF and AMI are described in the Figure. CONCLUSIONS: AMI-AF patients are older than AF patients without AMI at the time of new-onset AF. The diagnoses of AMI and AF tend to accumulate close to one another. One fourth of all AMI-AF patients were diagnosed with both diseases occurring same hospitalization period or within 30 days from new-onset AF. [Figure: see text]