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Assessment and correlation of anxiety, depression and serum cortisol levels in patients with oral submucous fibrosis and leukoplakia: A clinicohematological study
CONTEXT: Potentially malignant disorders (PMDs) of the oral cavity like oral submucous fibrosis (OSMF) and leukoplakia are known to be caused due to addictive habits, while serum cortisol is accepted to be a stress hormone. AIM: The present study was aimed to assess and correlate the anxiety, depres...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207224/ https://www.ncbi.nlm.nih.gov/pubmed/37234308 http://dx.doi.org/10.4103/jomfp.jomfp_1_22 |
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author | Manshi, P. Byatnal, Amit R. Ramesh, DNSV. Deshpande, Ashwini Reddy, Vikram Simha Najmuddin, M. |
author_facet | Manshi, P. Byatnal, Amit R. Ramesh, DNSV. Deshpande, Ashwini Reddy, Vikram Simha Najmuddin, M. |
author_sort | Manshi, P. |
collection | PubMed |
description | CONTEXT: Potentially malignant disorders (PMDs) of the oral cavity like oral submucous fibrosis (OSMF) and leukoplakia are known to be caused due to addictive habits, while serum cortisol is accepted to be a stress hormone. AIM: The present study was aimed to assess and correlate the anxiety, depression and serum cortisol levels in habit-associated PMDs such as OSMF and leukoplakia and compare it with healthy subjects. MATERIALS AND METHODS: Ninety patients were included in the study and were divided into three Groups, namely Group I (OSMF), Group II (leukoplakia) and Group III (control group). Serum cortisol levels and severity of anxiety and depression using the Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D) were recorded and correlated. RESULTS: A significant correlation existed between serum cortisol level and levels of both anxiety and depression between Group I and II as compared to the control group. CONCLUSION: There exists a definite correlation between serum cortisol levels and the levels of anxiety and depression in patients with leukoplakia and OSMF, with increasing levels of serum cortisol and higher values in both the HAM-A and HAM-D scales in patients with both OSMF and leukoplakia. PMDs such as leukoplakia and OSMF have an established cancer-causing potential. Anxiety and depression although prevalent are underdiagnosed and poorly understood. Hence, a holistic approach in the treatment of such pathologies including hematological investigations and psychological evaluation should be mandatorily made a part of the workup and treatment plan. |
format | Online Article Text |
id | pubmed-10207224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-102072242023-05-25 Assessment and correlation of anxiety, depression and serum cortisol levels in patients with oral submucous fibrosis and leukoplakia: A clinicohematological study Manshi, P. Byatnal, Amit R. Ramesh, DNSV. Deshpande, Ashwini Reddy, Vikram Simha Najmuddin, M. J Oral Maxillofac Pathol Original Article CONTEXT: Potentially malignant disorders (PMDs) of the oral cavity like oral submucous fibrosis (OSMF) and leukoplakia are known to be caused due to addictive habits, while serum cortisol is accepted to be a stress hormone. AIM: The present study was aimed to assess and correlate the anxiety, depression and serum cortisol levels in habit-associated PMDs such as OSMF and leukoplakia and compare it with healthy subjects. MATERIALS AND METHODS: Ninety patients were included in the study and were divided into three Groups, namely Group I (OSMF), Group II (leukoplakia) and Group III (control group). Serum cortisol levels and severity of anxiety and depression using the Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D) were recorded and correlated. RESULTS: A significant correlation existed between serum cortisol level and levels of both anxiety and depression between Group I and II as compared to the control group. CONCLUSION: There exists a definite correlation between serum cortisol levels and the levels of anxiety and depression in patients with leukoplakia and OSMF, with increasing levels of serum cortisol and higher values in both the HAM-A and HAM-D scales in patients with both OSMF and leukoplakia. PMDs such as leukoplakia and OSMF have an established cancer-causing potential. Anxiety and depression although prevalent are underdiagnosed and poorly understood. Hence, a holistic approach in the treatment of such pathologies including hematological investigations and psychological evaluation should be mandatorily made a part of the workup and treatment plan. Medknow Publications & Media Pvt Ltd 2023 2023-03-21 /pmc/articles/PMC10207224/ /pubmed/37234308 http://dx.doi.org/10.4103/jomfp.jomfp_1_22 Text en Copyright: © 2023 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Manshi, P. Byatnal, Amit R. Ramesh, DNSV. Deshpande, Ashwini Reddy, Vikram Simha Najmuddin, M. Assessment and correlation of anxiety, depression and serum cortisol levels in patients with oral submucous fibrosis and leukoplakia: A clinicohematological study |
title | Assessment and correlation of anxiety, depression and serum cortisol levels in patients with oral submucous fibrosis and leukoplakia: A clinicohematological study |
title_full | Assessment and correlation of anxiety, depression and serum cortisol levels in patients with oral submucous fibrosis and leukoplakia: A clinicohematological study |
title_fullStr | Assessment and correlation of anxiety, depression and serum cortisol levels in patients with oral submucous fibrosis and leukoplakia: A clinicohematological study |
title_full_unstemmed | Assessment and correlation of anxiety, depression and serum cortisol levels in patients with oral submucous fibrosis and leukoplakia: A clinicohematological study |
title_short | Assessment and correlation of anxiety, depression and serum cortisol levels in patients with oral submucous fibrosis and leukoplakia: A clinicohematological study |
title_sort | assessment and correlation of anxiety, depression and serum cortisol levels in patients with oral submucous fibrosis and leukoplakia: a clinicohematological study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207224/ https://www.ncbi.nlm.nih.gov/pubmed/37234308 http://dx.doi.org/10.4103/jomfp.jomfp_1_22 |
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