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Label-Free Chemically and Molecularly Selective Magnetic Resonance Imaging
[Image: see text] Biomedical imaging, especially molecular imaging, has been a driving force in scientific discovery, technological innovation, and precision medicine in the past two decades. While substantial advances and discoveries in chemical biology have been made to develop molecular imaging p...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nanjing University and American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207347/ https://www.ncbi.nlm.nih.gov/pubmed/37235188 http://dx.doi.org/10.1021/cbmi.3c00019 |
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author | Wu, Tianhe Liu, Claire Thamizhchelvan, Anbu Mozhi Fleischer, Candace Peng, Xingui Liu, Guanshu Mao, Hui |
author_facet | Wu, Tianhe Liu, Claire Thamizhchelvan, Anbu Mozhi Fleischer, Candace Peng, Xingui Liu, Guanshu Mao, Hui |
author_sort | Wu, Tianhe |
collection | PubMed |
description | [Image: see text] Biomedical imaging, especially molecular imaging, has been a driving force in scientific discovery, technological innovation, and precision medicine in the past two decades. While substantial advances and discoveries in chemical biology have been made to develop molecular imaging probes and tracers, translating these exogenous agents to clinical application in precision medicine is a major challenge. Among the clinically accepted imaging modalities, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) exemplify the most effective and robust biomedical imaging tools. Both MRI and MRS enable a broad range of chemical, biological and clinical applications from determining molecular structures in biochemical analysis to imaging diagnosis and characterization of many diseases and image-guided interventions. Using chemical, biological, and nuclear magnetic resonance properties of specific endogenous metabolites and native MRI contrast-enhancing biomolecules, label-free molecular and cellular imaging with MRI can be achieved in biomedical research and clinical management of patients with various diseases. This review article outlines the chemical and biological bases of several label-free chemically and molecularly selective MRI and MRS methods that have been applied in imaging biomarker discovery, preclinical investigation, and image-guided clinical management. Examples are provided to demonstrate strategies for using endogenous probes to report the molecular, metabolic, physiological, and functional events and processes in living systems, including patients. Future perspectives on label-free molecular MRI and its challenges as well as potential solutions, including the use of rational design and engineered approaches to develop chemical and biological imaging probes to facilitate or combine with label-free molecular MRI, are discussed. |
format | Online Article Text |
id | pubmed-10207347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nanjing University and American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-102073472023-05-25 Label-Free Chemically and Molecularly Selective Magnetic Resonance Imaging Wu, Tianhe Liu, Claire Thamizhchelvan, Anbu Mozhi Fleischer, Candace Peng, Xingui Liu, Guanshu Mao, Hui Chem Biomed Imaging [Image: see text] Biomedical imaging, especially molecular imaging, has been a driving force in scientific discovery, technological innovation, and precision medicine in the past two decades. While substantial advances and discoveries in chemical biology have been made to develop molecular imaging probes and tracers, translating these exogenous agents to clinical application in precision medicine is a major challenge. Among the clinically accepted imaging modalities, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) exemplify the most effective and robust biomedical imaging tools. Both MRI and MRS enable a broad range of chemical, biological and clinical applications from determining molecular structures in biochemical analysis to imaging diagnosis and characterization of many diseases and image-guided interventions. Using chemical, biological, and nuclear magnetic resonance properties of specific endogenous metabolites and native MRI contrast-enhancing biomolecules, label-free molecular and cellular imaging with MRI can be achieved in biomedical research and clinical management of patients with various diseases. This review article outlines the chemical and biological bases of several label-free chemically and molecularly selective MRI and MRS methods that have been applied in imaging biomarker discovery, preclinical investigation, and image-guided clinical management. Examples are provided to demonstrate strategies for using endogenous probes to report the molecular, metabolic, physiological, and functional events and processes in living systems, including patients. Future perspectives on label-free molecular MRI and its challenges as well as potential solutions, including the use of rational design and engineered approaches to develop chemical and biological imaging probes to facilitate or combine with label-free molecular MRI, are discussed. Nanjing University and American Chemical Society 2023-04-12 /pmc/articles/PMC10207347/ /pubmed/37235188 http://dx.doi.org/10.1021/cbmi.3c00019 Text en © 2023 The Authors. Co-published by Nanjing University and American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Wu, Tianhe Liu, Claire Thamizhchelvan, Anbu Mozhi Fleischer, Candace Peng, Xingui Liu, Guanshu Mao, Hui Label-Free Chemically and Molecularly Selective Magnetic Resonance Imaging |
title | Label-Free Chemically
and Molecularly Selective Magnetic
Resonance Imaging |
title_full | Label-Free Chemically
and Molecularly Selective Magnetic
Resonance Imaging |
title_fullStr | Label-Free Chemically
and Molecularly Selective Magnetic
Resonance Imaging |
title_full_unstemmed | Label-Free Chemically
and Molecularly Selective Magnetic
Resonance Imaging |
title_short | Label-Free Chemically
and Molecularly Selective Magnetic
Resonance Imaging |
title_sort | label-free chemically
and molecularly selective magnetic
resonance imaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207347/ https://www.ncbi.nlm.nih.gov/pubmed/37235188 http://dx.doi.org/10.1021/cbmi.3c00019 |
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