Screening and Biological Evaluation of Soluble Epoxide Hydrolase Inhibitors: Assessing the Role of Hydrophobicity in the Pharmacophore-Guided Search of Novel Hits

[Image: see text] The human soluble epoxide hydrolase (sEH) is a bifunctional enzyme that modulates the levels of regulatory epoxy lipids. The hydrolase activity is carried out by a catalytic triad located at the center of a wide L-shaped binding site, which contains two hydrophobic subpockets at bo...

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Detalles Bibliográficos
Autores principales: Vázquez, Javier, Ginex, Tiziana, Herrero, Albert, Morisseau, Christophe, Hammock, Bruce D., Luque, F. Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207366/
https://www.ncbi.nlm.nih.gov/pubmed/37141492
http://dx.doi.org/10.1021/acs.jcim.3c00301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207366/
https://www.ncbi.nlm.nih.gov/pubmed/37141492
http://dx.doi.org/10.1021/acs.jcim.3c00301

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