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Screening and Biological Evaluation of Soluble Epoxide Hydrolase Inhibitors: Assessing the Role of Hydrophobicity in the Pharmacophore-Guided Search of Novel Hits

[Image: see text] The human soluble epoxide hydrolase (sEH) is a bifunctional enzyme that modulates the levels of regulatory epoxy lipids. The hydrolase activity is carried out by a catalytic triad located at the center of a wide L-shaped binding site, which contains two hydrophobic subpockets at bo...

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Detalles Bibliográficos
Autores principales:	Vázquez, Javier, Ginex, Tiziana, Herrero, Albert, Morisseau, Christophe, Hammock, Bruce D., Luque, F. Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207366/ https://www.ncbi.nlm.nih.gov/pubmed/37141492 http://dx.doi.org/10.1021/acs.jcim.3c00301

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