Pulmonary vein reconnection rates and lesion regression during repeat procedures in patients with recurrent arrhythmias after pulsed field ablation pulmonary vein isolation

FUNDING ACKNOWLEDGEMENTS: Type of funding sources: None. BACKGROUND: A novel multipolar pulsed-field ablation (PFA) catheter has recently been introduced for pulmonary vein isolation (PVI). Pre-market data showed high rates for PVI-durability during mandatory remapping studies 90 days after the first procedure. Post-market data on PVI durability and lesion regression, particularly in patients with recurrent atrial arrhythmias, are limited. PURPOSE: To characterize the findings on redo cases after previous PFA procedures. METHODS: Consecutive patients undergoing a redo procedure after an index PFA PVI between May 2021 and October 2022 were included. 3-D electro-anatomical maps (3D-EAM) were acquired in sinus rhythm at the beginning of the redo procedure and compared to the 3D-EAM acquired after ablation during the index procedure. PV-reconnection was assessed on a per-vein and per-patient level and the sites of reconnections were identified. Furthermore, lesions extent was compared between the two maps. RESULTS: Of 265 patients undergoing their first PFA PVI between May 2021 and August 2022, 26 (9.8%) patients with recurrent atrial tachyarrhythmia underwent a redo ablation. The phenotype prior to the first PVI was paroxysmal AF in three patients (12%), persistent AF in 85 patients (85%), and left atrial flutter in one (4%) patient. A 31 mm device was used in 81% of the patients. Posterior wall ablation in addition to PVI was performed in three patients. At the end of the first PFA procedure, 100/102 veins (98%, two common ostia) were isolated as evidenced by post ablation 3D-EAM (two LIPV’s could not be isolated). The recurring arrhythmias were AF, atypical flutter, both, and atrial tachycardia in 14 patients (54%), 5 patients (19%), 6 patients (23%) and 1 (4%) respectively. High-density 3D-EAM identified 65/100 (65%) PVs with persistent isolation. In 7 (27%) patients, all PVs were isolated. Reconnection occurred most frequently in the right inferior PV (11, 42%) followed by the left superior PV (9, 36%), the right superior PV (8, 31%), the left inferior PV (6, 27%), and the left common ostium (1, 50%). The predominant reconnection sites were located anterior of the superior veins, and on the inferior aspect of the right inferior PV (Figure). On the posterior wall, the distance between the lesions of the left pulmonary veins and the right pulmonary veins increased by a median of 5 mm [0, 10] between the index and Redo procedure. CONCLUSION: In patients with recurrent atrial arrhythmias after PFA PVI, PV reconnections were found in 73% of the patients and in 35% of the veins. The reconnections were most prevalent on the anterior aspects of the upper veins, as well as on the inferior aspect of the right inferior vein. [Figure: see text]