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Sex-specific differences in infranodal conduction properties in patients undergoing transcatheter aortic valve replacement

FUNDING ACKNOWLEDGEMENTS: Type of funding sources: None. BACKGROUND: Electrophysiological (EP) testing has been proposed for risk stratification of patients with left bundle branch block (LBBB) after transcatheter aortic valve replacement (TAVR). A uniform cut-off of 70ms for the His-Ventricular (HV...

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Autores principales: Serban, T, Knecht, S, Mannhart, M, Nestelberger, T, Kaiser, C, Leibundgut, G, Bischof, M, Sticherling, C, Kuehne, M, Badertscher, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207634/
http://dx.doi.org/10.1093/europace/euad122.649
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author Serban, T
Knecht, S
Mannhart, M
Nestelberger, T
Kaiser, C
Leibundgut, G
Bischof, M
Sticherling, C
Kuehne, M
Badertscher, P
author_facet Serban, T
Knecht, S
Mannhart, M
Nestelberger, T
Kaiser, C
Leibundgut, G
Bischof, M
Sticherling, C
Kuehne, M
Badertscher, P
author_sort Serban, T
collection PubMed
description FUNDING ACKNOWLEDGEMENTS: Type of funding sources: None. BACKGROUND: Electrophysiological (EP) testing has been proposed for risk stratification of patients with left bundle branch block (LBBB) after transcatheter aortic valve replacement (TAVR). A uniform cut-off of 70ms for the His-Ventricular (HV) interval has been proposed to trigger pacemaker implantation. However, sex-specific periprocedural data regarding infranodal conduction properties are lacking. PURPOSE: We aimed to compare the HV interval in men and women undergoing TAVR. METHODS: We analyzed consecutive prospectively included patients undergoing TAVR between June 2020 and June 2021 at a tertiary referral center. EP testing was performed in all patients pre- and post-valve deployment and in the case of LBBB additionally for a third time the following day. RESULTS: 127 patients were included (81 ± 7 years, 46% female). Median HV interval pre-valve deployment was 43 [37-50] ms vs 46 [42-53] ms in women and men, respectively (p=0.016). Nine patients underwent peri-procedural pacemaker (PM) implantation for third-degree AV-block. The median HV interval post-valve deployment was 54 [42-59] ms in women and 56 [51-61] ms in men (p=0.038). The median HV interval the day following TAVR in patients with LBBB was 45 [41-49] ms in women and 50 [48-62] ms in men (p=0.048). An HV interval ≥ 55 ms and ≥70 ms was present the day following TAVR in seven patients (24%, two females) and three patients (10%, one female). (Figure) CONCLUSION: Women have shorter HV intervals pre-and post-valve-deployment as well as the day following TAVR compared to men. Further studies evaluating sex-specific cut-offs for the HV interval are warranted. [Figure: see text]
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spelling pubmed-102076342023-05-25 Sex-specific differences in infranodal conduction properties in patients undergoing transcatheter aortic valve replacement Serban, T Knecht, S Mannhart, M Nestelberger, T Kaiser, C Leibundgut, G Bischof, M Sticherling, C Kuehne, M Badertscher, P Europace 9.3.8 - Invasive Diagnostic Methods FUNDING ACKNOWLEDGEMENTS: Type of funding sources: None. BACKGROUND: Electrophysiological (EP) testing has been proposed for risk stratification of patients with left bundle branch block (LBBB) after transcatheter aortic valve replacement (TAVR). A uniform cut-off of 70ms for the His-Ventricular (HV) interval has been proposed to trigger pacemaker implantation. However, sex-specific periprocedural data regarding infranodal conduction properties are lacking. PURPOSE: We aimed to compare the HV interval in men and women undergoing TAVR. METHODS: We analyzed consecutive prospectively included patients undergoing TAVR between June 2020 and June 2021 at a tertiary referral center. EP testing was performed in all patients pre- and post-valve deployment and in the case of LBBB additionally for a third time the following day. RESULTS: 127 patients were included (81 ± 7 years, 46% female). Median HV interval pre-valve deployment was 43 [37-50] ms vs 46 [42-53] ms in women and men, respectively (p=0.016). Nine patients underwent peri-procedural pacemaker (PM) implantation for third-degree AV-block. The median HV interval post-valve deployment was 54 [42-59] ms in women and 56 [51-61] ms in men (p=0.038). The median HV interval the day following TAVR in patients with LBBB was 45 [41-49] ms in women and 50 [48-62] ms in men (p=0.048). An HV interval ≥ 55 ms and ≥70 ms was present the day following TAVR in seven patients (24%, two females) and three patients (10%, one female). (Figure) CONCLUSION: Women have shorter HV intervals pre-and post-valve-deployment as well as the day following TAVR compared to men. Further studies evaluating sex-specific cut-offs for the HV interval are warranted. [Figure: see text] Oxford University Press 2023-05-24 /pmc/articles/PMC10207634/ http://dx.doi.org/10.1093/europace/euad122.649 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle 9.3.8 - Invasive Diagnostic Methods
Serban, T
Knecht, S
Mannhart, M
Nestelberger, T
Kaiser, C
Leibundgut, G
Bischof, M
Sticherling, C
Kuehne, M
Badertscher, P
Sex-specific differences in infranodal conduction properties in patients undergoing transcatheter aortic valve replacement
title Sex-specific differences in infranodal conduction properties in patients undergoing transcatheter aortic valve replacement
title_full Sex-specific differences in infranodal conduction properties in patients undergoing transcatheter aortic valve replacement
title_fullStr Sex-specific differences in infranodal conduction properties in patients undergoing transcatheter aortic valve replacement
title_full_unstemmed Sex-specific differences in infranodal conduction properties in patients undergoing transcatheter aortic valve replacement
title_short Sex-specific differences in infranodal conduction properties in patients undergoing transcatheter aortic valve replacement
title_sort sex-specific differences in infranodal conduction properties in patients undergoing transcatheter aortic valve replacement
topic 9.3.8 - Invasive Diagnostic Methods
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207634/
http://dx.doi.org/10.1093/europace/euad122.649
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