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Noninvasive stratification of ventricular substrate by electrocardiographic imaging
FUNDING ACKNOWLEDGEMENTS: Type of funding sources: None. INTRODUCTION: Abnormalities of cardiac activation and conduction velocity (CV) are known pro-arrhythmogenic factors. Electrocardiographic imaging (ECGI) is presented as a non-invasive tool for arrhythmogenic substrate analysis. However, electr...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207643/ http://dx.doi.org/10.1093/europace/euad122.295 |
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author | Reventos-Presmanes, J Hernandez-Romero, I Invers-Rubio, E Ferro, E Garre, P Borras, R Tolosana, J M Guasch, E Arbelo, E Porta-Sanchez, A Vazquez, S Guichard, J B Climent, A M Mont, L Roca-Luque, I |
author_facet | Reventos-Presmanes, J Hernandez-Romero, I Invers-Rubio, E Ferro, E Garre, P Borras, R Tolosana, J M Guasch, E Arbelo, E Porta-Sanchez, A Vazquez, S Guichard, J B Climent, A M Mont, L Roca-Luque, I |
author_sort | Reventos-Presmanes, J |
collection | PubMed |
description | FUNDING ACKNOWLEDGEMENTS: Type of funding sources: None. INTRODUCTION: Abnormalities of cardiac activation and conduction velocity (CV) are known pro-arrhythmogenic factors. Electrocardiographic imaging (ECGI) is presented as a non-invasive tool for arrhythmogenic substrate analysis. However, electrocardiographic features such propagation activation patterns, and CV are unknown in healthy subjects. In this study, ECGI technology has been evaluated for ventricular tissue stratification in patients with and without structural heart disease. METHODS: Nineteen patients were included in the study. The healthy ventricles group (Panel A) included 10 patients (8 males, 57 ± 6 years, NYHA = I and LVEF 61 ± 5 %) with normal baseline QRS and normal values of ventricular morphology, function and perfusion assessed by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR). The structural heart disease group (Panel B) included 9 patients (9 males, 66±6 years, NYHA 2±1 and LVEF 26±5%) with ischemic cardiomyopathy (ICM) confirmed by LGE-CMR and indication for ablation due to ventricular tachycardia. For each patient, fibrotic areas were identified by ventricular segmentation of the LGE-CMR and ventricles were regionalized in 16 regions. Epicardial electrograms were noninvasively reconstructed by ECGI, late activation time (LAT) and CV maps were calculated to study electrocardiographic features. RESULTS: – Ventricles with fibrosis secondary to ICM revealed heterogenous activation patters and higher activation time distribution compared to healthy ventricles (120 ms vs 80 ms; p<0.01). Density distribution of CV was evaluated in the 0-200 cm/s interval, patients with healthy ventricular tissue showed homogenous CV distribution whereas ICM patients presented higher concentration in the slow CV region with a maximum peak around 75 cm/s. Moreover, CV values were significantly lower in fibrotic myocardium present in patients with structural heart disease compared to healthy myocardium (77 ± 40 cm/s vs 114 ± 46 cm/s; p<0.01), Panel C anterior view. Non-fibrotic regions in the ischemic ventricle group, Panel C inferior view, presented similar CV distributions to healthy ventricular tissue (114 ± 46 cm/s vs 120 ± 48 cm/s; p = 0.14). CONCLUSIONS: ECGI can noninvasively identify fibrotic tissue by analysing ventricular activation and CV patterns. ECGI could be a potential early tool to identify patients at risk of sudden cardiac death. [Figure: see text] |
format | Online Article Text |
id | pubmed-10207643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-102076432023-05-25 Noninvasive stratification of ventricular substrate by electrocardiographic imaging Reventos-Presmanes, J Hernandez-Romero, I Invers-Rubio, E Ferro, E Garre, P Borras, R Tolosana, J M Guasch, E Arbelo, E Porta-Sanchez, A Vazquez, S Guichard, J B Climent, A M Mont, L Roca-Luque, I Europace 13.3 - Diagnostic Methods FUNDING ACKNOWLEDGEMENTS: Type of funding sources: None. INTRODUCTION: Abnormalities of cardiac activation and conduction velocity (CV) are known pro-arrhythmogenic factors. Electrocardiographic imaging (ECGI) is presented as a non-invasive tool for arrhythmogenic substrate analysis. However, electrocardiographic features such propagation activation patterns, and CV are unknown in healthy subjects. In this study, ECGI technology has been evaluated for ventricular tissue stratification in patients with and without structural heart disease. METHODS: Nineteen patients were included in the study. The healthy ventricles group (Panel A) included 10 patients (8 males, 57 ± 6 years, NYHA = I and LVEF 61 ± 5 %) with normal baseline QRS and normal values of ventricular morphology, function and perfusion assessed by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR). The structural heart disease group (Panel B) included 9 patients (9 males, 66±6 years, NYHA 2±1 and LVEF 26±5%) with ischemic cardiomyopathy (ICM) confirmed by LGE-CMR and indication for ablation due to ventricular tachycardia. For each patient, fibrotic areas were identified by ventricular segmentation of the LGE-CMR and ventricles were regionalized in 16 regions. Epicardial electrograms were noninvasively reconstructed by ECGI, late activation time (LAT) and CV maps were calculated to study electrocardiographic features. RESULTS: – Ventricles with fibrosis secondary to ICM revealed heterogenous activation patters and higher activation time distribution compared to healthy ventricles (120 ms vs 80 ms; p<0.01). Density distribution of CV was evaluated in the 0-200 cm/s interval, patients with healthy ventricular tissue showed homogenous CV distribution whereas ICM patients presented higher concentration in the slow CV region with a maximum peak around 75 cm/s. Moreover, CV values were significantly lower in fibrotic myocardium present in patients with structural heart disease compared to healthy myocardium (77 ± 40 cm/s vs 114 ± 46 cm/s; p<0.01), Panel C anterior view. Non-fibrotic regions in the ischemic ventricle group, Panel C inferior view, presented similar CV distributions to healthy ventricular tissue (114 ± 46 cm/s vs 120 ± 48 cm/s; p = 0.14). CONCLUSIONS: ECGI can noninvasively identify fibrotic tissue by analysing ventricular activation and CV patterns. ECGI could be a potential early tool to identify patients at risk of sudden cardiac death. [Figure: see text] Oxford University Press 2023-05-24 /pmc/articles/PMC10207643/ http://dx.doi.org/10.1093/europace/euad122.295 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | 13.3 - Diagnostic Methods Reventos-Presmanes, J Hernandez-Romero, I Invers-Rubio, E Ferro, E Garre, P Borras, R Tolosana, J M Guasch, E Arbelo, E Porta-Sanchez, A Vazquez, S Guichard, J B Climent, A M Mont, L Roca-Luque, I Noninvasive stratification of ventricular substrate by electrocardiographic imaging |
title | Noninvasive stratification of ventricular substrate by electrocardiographic imaging |
title_full | Noninvasive stratification of ventricular substrate by electrocardiographic imaging |
title_fullStr | Noninvasive stratification of ventricular substrate by electrocardiographic imaging |
title_full_unstemmed | Noninvasive stratification of ventricular substrate by electrocardiographic imaging |
title_short | Noninvasive stratification of ventricular substrate by electrocardiographic imaging |
title_sort | noninvasive stratification of ventricular substrate by electrocardiographic imaging |
topic | 13.3 - Diagnostic Methods |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207643/ http://dx.doi.org/10.1093/europace/euad122.295 |
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