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The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update

Prior to the coronavirus disease-19 (COVID-19) pandemic, the germicidal effects of visible light (λ = 400 – 700 nm) were well known. This review provides an overview of new findings that suggest there are direct inactivating effects of visible light – particularly blue wavelengths (λ = 400 – 500 nm)...

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Autor principal: Gorman, Shelley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author. Published by Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207839/
https://www.ncbi.nlm.nih.gov/pubmed/37288364
http://dx.doi.org/10.1016/j.jpap.2023.100187
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description Prior to the coronavirus disease-19 (COVID-19) pandemic, the germicidal effects of visible light (λ = 400 – 700 nm) were well known. This review provides an overview of new findings that suggest there are direct inactivating effects of visible light – particularly blue wavelengths (λ = 400 – 500 nm) – on exposed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions, and inhibitory effects on viral replication in infected cells. These findings complement emerging evidence that there may be clinical benefits of orally administered blue light for limiting the severity of COVID-19. Possible mechanisms of action of blue light (e.g., regulation of reactive oxygen species) and important mediators (e.g., melatonin) are discussed.
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spelling pubmed-102078392023-05-24 The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update Gorman, Shelley J Photochem Photobiol Article Prior to the coronavirus disease-19 (COVID-19) pandemic, the germicidal effects of visible light (λ = 400 – 700 nm) were well known. This review provides an overview of new findings that suggest there are direct inactivating effects of visible light – particularly blue wavelengths (λ = 400 – 500 nm) – on exposed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions, and inhibitory effects on viral replication in infected cells. These findings complement emerging evidence that there may be clinical benefits of orally administered blue light for limiting the severity of COVID-19. Possible mechanisms of action of blue light (e.g., regulation of reactive oxygen species) and important mediators (e.g., melatonin) are discussed. The Author. Published by Elsevier B.V. 2023-06 2023-05-24 /pmc/articles/PMC10207839/ /pubmed/37288364 http://dx.doi.org/10.1016/j.jpap.2023.100187 Text en © 2023 The Author Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gorman, Shelley
The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update
title The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update
title_full The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update
title_fullStr The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update
title_full_unstemmed The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update
title_short The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update
title_sort inhibitory and inactivating effects of visible light on sars-cov-2: a narrative update
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207839/
https://www.ncbi.nlm.nih.gov/pubmed/37288364
http://dx.doi.org/10.1016/j.jpap.2023.100187
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