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Sex, Age, and Regional Differences in CHRM1 and CHRM3 Genes Expression Levels in the Human Brain Biopsies: Potential Targets for Alzheimer's Disease-related Sleep Disturbances

BACKGROUND: Cholinergic hypofunction and sleep disturbance are hallmarks of Alzheimer’s disease (AD), a progressive disorder leading to neuronal deterioration. Muscarinic acetylcholine receptors (M1-5 or mAChRs), expressed in hippocampus and cerebral cortex, play a pivotal role in the aberrant alter...

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Detalles Bibliográficos
Autores principales:	Sanfilippo, Cristina, Giuliano, Loretta, Castrogiovanni, Paola, Imbesi, Rosa, Ulivieri, Martina, Fazio, Francesco, Blennow, Kaj, Zetterberg, Henrik, Di Rosa, Michelino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2023
Materias:	Medicine, Neurology, Pharmacology, Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207911/ https://www.ncbi.nlm.nih.gov/pubmed/36475335 http://dx.doi.org/10.2174/1570159X21666221207091209

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