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Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy

BACKGROUND: Major depressive disorders represent a significant burden to society, and it is recommended that antidepressant therapy should last at least 6 months. In Italy, antidepressant use in clinical practice was reported to increase by 1.7% in 2020 compared to 2019, but only 40% of new prescrip...

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Autores principales: Di Nicola, Marco, Dell’Osso, Bernardo, Peduto, Ilaria, Cipelli, Riccardo, Pugliese, Anna Cristina, Signorelli, Maria Salvina, Ventriglio, Antonio, Martinotti, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207922/
https://www.ncbi.nlm.nih.gov/pubmed/35410606
http://dx.doi.org/10.2174/1570159X20666220411092813
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author Di Nicola, Marco
Dell’Osso, Bernardo
Peduto, Ilaria
Cipelli, Riccardo
Pugliese, Anna Cristina
Signorelli, Maria Salvina
Ventriglio, Antonio
Martinotti, Giovanni
author_facet Di Nicola, Marco
Dell’Osso, Bernardo
Peduto, Ilaria
Cipelli, Riccardo
Pugliese, Anna Cristina
Signorelli, Maria Salvina
Ventriglio, Antonio
Martinotti, Giovanni
author_sort Di Nicola, Marco
collection PubMed
description BACKGROUND: Major depressive disorders represent a significant burden to society, and it is recommended that antidepressant therapy should last at least 6 months. In Italy, antidepressant use in clinical practice was reported to increase by 1.7% in 2020 compared to 2019, but only 40% of new prescriptions are characterized by a treatment duration longer than 3 months. OBJECTIVE: The study aims to describe adherence and persistence to therapy in a subset of antidepressants (citalopram, duloxetine, escitalopram, paroxetine, sertraline, venlafaxine) vs. vortioxetine in Italy during a 2-year period from 2017 to 2019. METHODS: A retrospective analysis of the longitudinal patient database reporting data from general practitioners on drug prescriptions in Italy was carried out in a cohort of 8,235 adult patients who were prescribed antidepressants. RESULTS: Overall, 32.4% of the patients adhered to treatment for ≥6 months over a 1-year period. Vortioxetine had a lower risk of low adherence compared to duloxetine, paroxetine, and venlafaxine and a higher risk compared to citalopram, escitalopram, and sertraline. 68.7% of patients discontinued treatment during follow-up. The greatest percentage of patients continuing therapy was seen with duloxetine, while citalopram was associated with the highest proportion of patients discontinuing therapy. No significant differences in discontinuation were observed when comparing vortioxetine to the other antidepressants. CONCLUSION: Adherence results were considerably less than the 6-month recommendation in this real-world analysis of antidepressant therapies. Also, persistence to therapy was low, with most patients discontinuing treatment. Thus, there is a need for interventions to help patients adhere to their planned therapy.
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spelling pubmed-102079222023-06-15 Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy Di Nicola, Marco Dell’Osso, Bernardo Peduto, Ilaria Cipelli, Riccardo Pugliese, Anna Cristina Signorelli, Maria Salvina Ventriglio, Antonio Martinotti, Giovanni Curr Neuropharmacol Medicine, Neurology, Pharmacology, Neuroscience BACKGROUND: Major depressive disorders represent a significant burden to society, and it is recommended that antidepressant therapy should last at least 6 months. In Italy, antidepressant use in clinical practice was reported to increase by 1.7% in 2020 compared to 2019, but only 40% of new prescriptions are characterized by a treatment duration longer than 3 months. OBJECTIVE: The study aims to describe adherence and persistence to therapy in a subset of antidepressants (citalopram, duloxetine, escitalopram, paroxetine, sertraline, venlafaxine) vs. vortioxetine in Italy during a 2-year period from 2017 to 2019. METHODS: A retrospective analysis of the longitudinal patient database reporting data from general practitioners on drug prescriptions in Italy was carried out in a cohort of 8,235 adult patients who were prescribed antidepressants. RESULTS: Overall, 32.4% of the patients adhered to treatment for ≥6 months over a 1-year period. Vortioxetine had a lower risk of low adherence compared to duloxetine, paroxetine, and venlafaxine and a higher risk compared to citalopram, escitalopram, and sertraline. 68.7% of patients discontinued treatment during follow-up. The greatest percentage of patients continuing therapy was seen with duloxetine, while citalopram was associated with the highest proportion of patients discontinuing therapy. No significant differences in discontinuation were observed when comparing vortioxetine to the other antidepressants. CONCLUSION: Adherence results were considerably less than the 6-month recommendation in this real-world analysis of antidepressant therapies. Also, persistence to therapy was low, with most patients discontinuing treatment. Thus, there is a need for interventions to help patients adhere to their planned therapy. Bentham Science Publishers 2023-03-08 2023-03-08 /pmc/articles/PMC10207922/ /pubmed/35410606 http://dx.doi.org/10.2174/1570159X20666220411092813 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
spellingShingle Medicine, Neurology, Pharmacology, Neuroscience
Di Nicola, Marco
Dell’Osso, Bernardo
Peduto, Ilaria
Cipelli, Riccardo
Pugliese, Anna Cristina
Signorelli, Maria Salvina
Ventriglio, Antonio
Martinotti, Giovanni
Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy
title Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy
title_full Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy
title_fullStr Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy
title_full_unstemmed Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy
title_short Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy
title_sort adherence to, and persistence of, antidepressant therapy in patients with major depressive disorder: results from a population-based study in italy
topic Medicine, Neurology, Pharmacology, Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207922/
https://www.ncbi.nlm.nih.gov/pubmed/35410606
http://dx.doi.org/10.2174/1570159X20666220411092813
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