Anticancer efficacy of 3-(4-isopropyl) benzylidene-8-ethoxy, 6-methyl, chroman-4-one (SBL-060), a novel, dual, estrogen receptor-Akt kinase inhibitor in acute myeloid leukemia cells

Estrogen receptor (ER) α is expressed in a subset of patient-derived acute myeloid leukemia (AML) cells, whereas Akt is predominantly expressed in most types of AML. Targeting AML with dual inhibitors is a novel approach to combat the disease. Herein, we examined a novel small molecule, 3-(4-isoprop...

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Detalles Bibliográficos
Autores principales: SHAHRANI, MESFER AL, RAJAGOPALAN, PRASANNA, ABOHASSAN, MOHAMMAD, ALSHAHRANI, MOHAMMAD, ALRAEY, YASSER, GAHTANI, REEM M., RADHAKRISHNAN, SURESH, DAGREERY, KHLOOD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207952/
https://www.ncbi.nlm.nih.gov/pubmed/37304671
http://dx.doi.org/10.32604/or.2022.03539

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