The tumor suppressor role and ceRNA network of miR-1294 in cancer

miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells. The target genes of...

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Autores principales: MAO, YUNAN, SHEN, JINZE, FANG, LI, ZHU, FENG, DUAN, SHIWEI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207999/
https://www.ncbi.nlm.nih.gov/pubmed/37303740
http://dx.doi.org/10.32604/or.2022.027359
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author MAO, YUNAN
SHEN, JINZE
FANG, LI
ZHU, FENG
DUAN, SHIWEI
author_facet MAO, YUNAN
SHEN, JINZE
FANG, LI
ZHU, FENG
DUAN, SHIWEI
author_sort MAO, YUNAN
collection PubMed
description miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR, RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC, PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and provides a basis for the clinical significance of the tumor suppressor miR-1294 in cancer.
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spelling pubmed-102079992023-06-10 The tumor suppressor role and ceRNA network of miR-1294 in cancer MAO, YUNAN SHEN, JINZE FANG, LI ZHU, FENG DUAN, SHIWEI Oncol Res Review miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR, RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC, PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and provides a basis for the clinical significance of the tumor suppressor miR-1294 in cancer. Tech Science Press 2023-03-01 /pmc/articles/PMC10207999/ /pubmed/37303740 http://dx.doi.org/10.32604/or.2022.027359 Text en © 2023 Mao et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
MAO, YUNAN
SHEN, JINZE
FANG, LI
ZHU, FENG
DUAN, SHIWEI
The tumor suppressor role and ceRNA network of miR-1294 in cancer
title The tumor suppressor role and ceRNA network of miR-1294 in cancer
title_full The tumor suppressor role and ceRNA network of miR-1294 in cancer
title_fullStr The tumor suppressor role and ceRNA network of miR-1294 in cancer
title_full_unstemmed The tumor suppressor role and ceRNA network of miR-1294 in cancer
title_short The tumor suppressor role and ceRNA network of miR-1294 in cancer
title_sort tumor suppressor role and cerna network of mir-1294 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207999/
https://www.ncbi.nlm.nih.gov/pubmed/37303740
http://dx.doi.org/10.32604/or.2022.027359
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