The role of LIN28B in tumor progression and metastasis in solid tumor entities

LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelia...

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Autores principales: GEWALT, TABEA, NOH, KA-WON, MEDER, LYDIA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208000/
https://www.ncbi.nlm.nih.gov/pubmed/37304235
http://dx.doi.org/10.32604/or.2023.028105
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author GEWALT, TABEA
NOH, KA-WON
MEDER, LYDIA
author_facet GEWALT, TABEA
NOH, KA-WON
MEDER, LYDIA
author_sort GEWALT, TABEA
collection PubMed
description LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs. In malignancies, LIN28B is frequently overexpressed, which is associated with increased tumor aggressiveness and metastatic properties. In this review, we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.
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spelling pubmed-102080002023-06-10 The role of LIN28B in tumor progression and metastasis in solid tumor entities GEWALT, TABEA NOH, KA-WON MEDER, LYDIA Oncol Res Review LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs. In malignancies, LIN28B is frequently overexpressed, which is associated with increased tumor aggressiveness and metastatic properties. In this review, we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker. Tech Science Press 2023-04-10 /pmc/articles/PMC10208000/ /pubmed/37304235 http://dx.doi.org/10.32604/or.2023.028105 Text en © 2023 Gewalt, Noh and Meder https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
GEWALT, TABEA
NOH, KA-WON
MEDER, LYDIA
The role of LIN28B in tumor progression and metastasis in solid tumor entities
title The role of LIN28B in tumor progression and metastasis in solid tumor entities
title_full The role of LIN28B in tumor progression and metastasis in solid tumor entities
title_fullStr The role of LIN28B in tumor progression and metastasis in solid tumor entities
title_full_unstemmed The role of LIN28B in tumor progression and metastasis in solid tumor entities
title_short The role of LIN28B in tumor progression and metastasis in solid tumor entities
title_sort role of lin28b in tumor progression and metastasis in solid tumor entities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208000/
https://www.ncbi.nlm.nih.gov/pubmed/37304235
http://dx.doi.org/10.32604/or.2023.028105
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