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Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant E. coli

The growing antibiotic resistance, foremost in Gram-negative bacteria, requires novel therapeutic approaches. We aimed to enhance the potency of well-established antibiotics targeting the RNA polymerase (RNAP) by utilizing the microbial iron transport machinery to improve drug translocation across t...

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Detalles Bibliográficos
Autores principales:	Peukert, Carsten, Vetter, Anna C., Fuchs, Hazel L. S., Harmrolfs, Kirsten, Karge, Bianka, Stadler, Marc, Brönstrup, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208051/ https://www.ncbi.nlm.nih.gov/pubmed/37234900 http://dx.doi.org/10.1039/d2sc06850h

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