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The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV are expressed in HPV-positive cancers and associated with the early cancer stages and the transformation of normal cells. Th...

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Autores principales: AGHBASH, PARISA SHIRI, HEMMAT, NIMA, BARADARAN, BEHZAD, MOKHTARZADEH, AHAD, POORTAHMASEBI, VAHDAT, OSKUEE, MAHIN AHANGAR, BAGHI, HOSSEIN BANNAZADEH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208084/
https://www.ncbi.nlm.nih.gov/pubmed/37305016
http://dx.doi.org/10.32604/or.2022.026776
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author AGHBASH, PARISA SHIRI
HEMMAT, NIMA
BARADARAN, BEHZAD
MOKHTARZADEH, AHAD
POORTAHMASEBI, VAHDAT
OSKUEE, MAHIN AHANGAR
BAGHI, HOSSEIN BANNAZADEH
author_facet AGHBASH, PARISA SHIRI
HEMMAT, NIMA
BARADARAN, BEHZAD
MOKHTARZADEH, AHAD
POORTAHMASEBI, VAHDAT
OSKUEE, MAHIN AHANGAR
BAGHI, HOSSEIN BANNAZADEH
author_sort AGHBASH, PARISA SHIRI
collection PubMed
description Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV are expressed in HPV-positive cancers and associated with the early cancer stages and the transformation of normal cells. The signaling pathways involved in the transformation of normal cells to cancerous form and the subsequently expressed programmed cell death-ligand 1 (PD-L1) on the surface of the transformed cells lead to a disruption in recognition of tumor cells by the immune cell system, including T lymphocytes and dendritic cells which lead to the development of cervical cancer malignancy. These cells also produce modest levels of cytokines during exhaustion, tumor-infiltrating T CD4+ cells with high levels of PD-1 and CD39 release considerable quantities of cytokines. The Wnt/β-catenin signaling pathway, which controls the expression of genes involved in the tumor cells’ markers, is demonstrated to be one of the most potent cancer stimulants. It leads to the evasion of the tumor cells from immune cell detection and ultimately avoids being recognized by dendritic cells or T-cells. PD-L1, as an inhibitory immune checkpoint, is essential for controlling immune system activity by inhibiting T-cells’ inflammatory function. In the present review, we looked into how Wnt/β-catenin affects the expression of PD-L1 and related genes like c-MYC in cancer cells and its role in the development of HPV-induced malignancy. We hypothesized that blocking these pathways could be a potential immunotherapy and cancer prevention method.
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spelling pubmed-102080842023-06-10 The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer AGHBASH, PARISA SHIRI HEMMAT, NIMA BARADARAN, BEHZAD MOKHTARZADEH, AHAD POORTAHMASEBI, VAHDAT OSKUEE, MAHIN AHANGAR BAGHI, HOSSEIN BANNAZADEH Oncol Res Review Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV are expressed in HPV-positive cancers and associated with the early cancer stages and the transformation of normal cells. The signaling pathways involved in the transformation of normal cells to cancerous form and the subsequently expressed programmed cell death-ligand 1 (PD-L1) on the surface of the transformed cells lead to a disruption in recognition of tumor cells by the immune cell system, including T lymphocytes and dendritic cells which lead to the development of cervical cancer malignancy. These cells also produce modest levels of cytokines during exhaustion, tumor-infiltrating T CD4+ cells with high levels of PD-1 and CD39 release considerable quantities of cytokines. The Wnt/β-catenin signaling pathway, which controls the expression of genes involved in the tumor cells’ markers, is demonstrated to be one of the most potent cancer stimulants. It leads to the evasion of the tumor cells from immune cell detection and ultimately avoids being recognized by dendritic cells or T-cells. PD-L1, as an inhibitory immune checkpoint, is essential for controlling immune system activity by inhibiting T-cells’ inflammatory function. In the present review, we looked into how Wnt/β-catenin affects the expression of PD-L1 and related genes like c-MYC in cancer cells and its role in the development of HPV-induced malignancy. We hypothesized that blocking these pathways could be a potential immunotherapy and cancer prevention method. Tech Science Press 2023-01-12 /pmc/articles/PMC10208084/ /pubmed/37305016 http://dx.doi.org/10.32604/or.2022.026776 Text en © 2022 Aghbash et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
AGHBASH, PARISA SHIRI
HEMMAT, NIMA
BARADARAN, BEHZAD
MOKHTARZADEH, AHAD
POORTAHMASEBI, VAHDAT
OSKUEE, MAHIN AHANGAR
BAGHI, HOSSEIN BANNAZADEH
The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer
title The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer
title_full The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer
title_fullStr The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer
title_full_unstemmed The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer
title_short The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer
title_sort effect of wnt/β-catenin signaling on pd-1/pdl-1 axis in hpv-related cervical cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208084/
https://www.ncbi.nlm.nih.gov/pubmed/37305016
http://dx.doi.org/10.32604/or.2022.026776
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