Cargando…

Cell cycle oscillations driven by two interlinked bistable switches

Regular transitions between interphase and mitosis during the cell cycle are driven by changes in the activity of the enzymatic protein complex cyclin B with cyclin-dependent kinase 1 (Cdk1). At the most basic level, this cell cycle oscillator is driven by negative feedback: active cyclin B-Cdk1 act...

Descripción completa

Detalles Bibliográficos
Autores principales: Parra-Rivas, Pedro, Ruiz-Reynés, Daniel, Gelens, Lendert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208103/
https://www.ncbi.nlm.nih.gov/pubmed/36790907
http://dx.doi.org/10.1091/mbc.E22-11-0527
_version_ 1785046600834351104
author Parra-Rivas, Pedro
Ruiz-Reynés, Daniel
Gelens, Lendert
author_facet Parra-Rivas, Pedro
Ruiz-Reynés, Daniel
Gelens, Lendert
author_sort Parra-Rivas, Pedro
collection PubMed
description Regular transitions between interphase and mitosis during the cell cycle are driven by changes in the activity of the enzymatic protein complex cyclin B with cyclin-dependent kinase 1 (Cdk1). At the most basic level, this cell cycle oscillator is driven by negative feedback: active cyclin B-Cdk1 activates the anaphase-promoting complex/cyclosome, which triggers the degradation of cyclin B. Such cell cycle oscillations occur fast and periodically in the early embryos of the frog Xenopus laevis, where several positive-feedback loops leading to bistable switches in parts of the regulatory network have been experimentally identified. Here, we build cell cycle oscillator models to show how single and multiple bistable switches in parts of the underlying regulatory network change the properties of the oscillations and how they can confer robustness to the oscillator. We present a detailed bifurcation analysis of these models.
format Online
Article
Text
id pubmed-10208103
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The American Society for Cell Biology
record_format MEDLINE/PubMed
spelling pubmed-102081032023-07-20 Cell cycle oscillations driven by two interlinked bistable switches Parra-Rivas, Pedro Ruiz-Reynés, Daniel Gelens, Lendert Mol Biol Cell Articles Regular transitions between interphase and mitosis during the cell cycle are driven by changes in the activity of the enzymatic protein complex cyclin B with cyclin-dependent kinase 1 (Cdk1). At the most basic level, this cell cycle oscillator is driven by negative feedback: active cyclin B-Cdk1 activates the anaphase-promoting complex/cyclosome, which triggers the degradation of cyclin B. Such cell cycle oscillations occur fast and periodically in the early embryos of the frog Xenopus laevis, where several positive-feedback loops leading to bistable switches in parts of the regulatory network have been experimentally identified. Here, we build cell cycle oscillator models to show how single and multiple bistable switches in parts of the underlying regulatory network change the properties of the oscillations and how they can confer robustness to the oscillator. We present a detailed bifurcation analysis of these models. The American Society for Cell Biology 2023-05-05 /pmc/articles/PMC10208103/ /pubmed/36790907 http://dx.doi.org/10.1091/mbc.E22-11-0527 Text en © 2023 Parra-Rivas, Ruiz-Reynés, and Gelens. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial-Share Alike 4.0 International Creative Commons License.
spellingShingle Articles
Parra-Rivas, Pedro
Ruiz-Reynés, Daniel
Gelens, Lendert
Cell cycle oscillations driven by two interlinked bistable switches
title Cell cycle oscillations driven by two interlinked bistable switches
title_full Cell cycle oscillations driven by two interlinked bistable switches
title_fullStr Cell cycle oscillations driven by two interlinked bistable switches
title_full_unstemmed Cell cycle oscillations driven by two interlinked bistable switches
title_short Cell cycle oscillations driven by two interlinked bistable switches
title_sort cell cycle oscillations driven by two interlinked bistable switches
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208103/
https://www.ncbi.nlm.nih.gov/pubmed/36790907
http://dx.doi.org/10.1091/mbc.E22-11-0527
work_keys_str_mv AT parrarivaspedro cellcycleoscillationsdrivenbytwointerlinkedbistableswitches
AT ruizreynesdaniel cellcycleoscillationsdrivenbytwointerlinkedbistableswitches
AT gelenslendert cellcycleoscillationsdrivenbytwointerlinkedbistableswitches