GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of VHHs, we explored the VHH scaffold in a structure-guided app...

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Detalles Bibliográficos
Autores principales: van Schie, Loes, Van Breedam, Wander, Roels, Charlotte, Schepens, Bert, Frank, Martin, Mehdipour, Ahmad Reza, Laukens, Bram, Nerinckx, Wim, Santens, Francis, Devos, Simon, Rossey, Iebe, Thooft, Karel, Vanmarcke, Sandrine, Van Hecke, Annelies, Saelens, Xavier, Callewaert, Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208171/
https://www.ncbi.nlm.nih.gov/pubmed/37211816
http://dx.doi.org/10.1080/19420862.2023.2210709

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