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Pupillary response is associated with the reset and switching of functional brain networks during salience processing
The interface between processing internal goals and salient events in the environment involves various top-down processes. Previous studies have identified multiple brain areas for salience processing, including the salience network (SN), dorsal attention network, and the locus coeruleus-norepinephr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208478/ https://www.ncbi.nlm.nih.gov/pubmed/37172067 http://dx.doi.org/10.1371/journal.pcbi.1011081 |
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author | He, Hengda Hong, Linbi Sajda, Paul |
author_facet | He, Hengda Hong, Linbi Sajda, Paul |
author_sort | He, Hengda |
collection | PubMed |
description | The interface between processing internal goals and salient events in the environment involves various top-down processes. Previous studies have identified multiple brain areas for salience processing, including the salience network (SN), dorsal attention network, and the locus coeruleus-norepinephrine (LC-NE) system. However, interactions among these systems in salience processing remain unclear. Here, we simultaneously recorded pupillometry, EEG, and fMRI during an auditory oddball paradigm. The analyses of EEG and fMRI data uncovered spatiotemporally organized target-associated neural correlates. By modeling the target-modulated effective connectivity, we found that the target-evoked pupillary response is associated with the network directional couplings from late to early subsystems in the trial, as well as the network switching initiated by the SN. These findings indicate that the SN might cooperate with the pupil-indexed LC-NE system in the reset and switching of cortical networks, and shed light on their implications in various cognitive processes and neurological diseases. |
format | Online Article Text |
id | pubmed-10208478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-102084782023-05-25 Pupillary response is associated with the reset and switching of functional brain networks during salience processing He, Hengda Hong, Linbi Sajda, Paul PLoS Comput Biol Research Article The interface between processing internal goals and salient events in the environment involves various top-down processes. Previous studies have identified multiple brain areas for salience processing, including the salience network (SN), dorsal attention network, and the locus coeruleus-norepinephrine (LC-NE) system. However, interactions among these systems in salience processing remain unclear. Here, we simultaneously recorded pupillometry, EEG, and fMRI during an auditory oddball paradigm. The analyses of EEG and fMRI data uncovered spatiotemporally organized target-associated neural correlates. By modeling the target-modulated effective connectivity, we found that the target-evoked pupillary response is associated with the network directional couplings from late to early subsystems in the trial, as well as the network switching initiated by the SN. These findings indicate that the SN might cooperate with the pupil-indexed LC-NE system in the reset and switching of cortical networks, and shed light on their implications in various cognitive processes and neurological diseases. Public Library of Science 2023-05-12 /pmc/articles/PMC10208478/ /pubmed/37172067 http://dx.doi.org/10.1371/journal.pcbi.1011081 Text en © 2023 He et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article He, Hengda Hong, Linbi Sajda, Paul Pupillary response is associated with the reset and switching of functional brain networks during salience processing |
title | Pupillary response is associated with the reset and switching of functional brain networks during salience processing |
title_full | Pupillary response is associated with the reset and switching of functional brain networks during salience processing |
title_fullStr | Pupillary response is associated with the reset and switching of functional brain networks during salience processing |
title_full_unstemmed | Pupillary response is associated with the reset and switching of functional brain networks during salience processing |
title_short | Pupillary response is associated with the reset and switching of functional brain networks during salience processing |
title_sort | pupillary response is associated with the reset and switching of functional brain networks during salience processing |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208478/ https://www.ncbi.nlm.nih.gov/pubmed/37172067 http://dx.doi.org/10.1371/journal.pcbi.1011081 |
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