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Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis
We present the case of a 32-year-old healthy male who presented with a three-month history of insidious onset pain and swelling over the right tibia. Initial radiographs and imaging pointed to a diagnosis of subacute osteomyelitis, as there was no cortical destruction, periosteal reaction, or soft t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208550/ https://www.ncbi.nlm.nih.gov/pubmed/37234139 http://dx.doi.org/10.7759/cureus.38070 |
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author | Jayaprakasan, Prabhakaran Warrier, Arun |
author_facet | Jayaprakasan, Prabhakaran Warrier, Arun |
author_sort | Jayaprakasan, Prabhakaran |
collection | PubMed |
description | We present the case of a 32-year-old healthy male who presented with a three-month history of insidious onset pain and swelling over the right tibia. Initial radiographs and imaging pointed to a diagnosis of subacute osteomyelitis, as there was no cortical destruction, periosteal reaction, or soft tissue involvement. The patient underwent surgery for osteomyelitis. However, the histopathology and immunohistochemistry (IHC) findings pointed to a possible B-cell lymphoma diagnosis. The patient was referred to a tertiary-level oncology centre, where a repeat biopsy and positron emission tomography (PET) scan confirmed a diagnosis of primary bone lymphoma (PBL). Treatment was initiated immediately in the form of a combination of chemotherapy and radiotherapy, and the progress was followed up with further scans at four-month intervals. The patient achieved remission nine months after the initiation of treatment. |
format | Online Article Text |
id | pubmed-10208550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-102085502023-05-25 Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis Jayaprakasan, Prabhakaran Warrier, Arun Cureus Pathology We present the case of a 32-year-old healthy male who presented with a three-month history of insidious onset pain and swelling over the right tibia. Initial radiographs and imaging pointed to a diagnosis of subacute osteomyelitis, as there was no cortical destruction, periosteal reaction, or soft tissue involvement. The patient underwent surgery for osteomyelitis. However, the histopathology and immunohistochemistry (IHC) findings pointed to a possible B-cell lymphoma diagnosis. The patient was referred to a tertiary-level oncology centre, where a repeat biopsy and positron emission tomography (PET) scan confirmed a diagnosis of primary bone lymphoma (PBL). Treatment was initiated immediately in the form of a combination of chemotherapy and radiotherapy, and the progress was followed up with further scans at four-month intervals. The patient achieved remission nine months after the initiation of treatment. Cureus 2023-04-24 /pmc/articles/PMC10208550/ /pubmed/37234139 http://dx.doi.org/10.7759/cureus.38070 Text en Copyright © 2023, Jayaprakasan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pathology Jayaprakasan, Prabhakaran Warrier, Arun Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis |
title | Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis |
title_full | Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis |
title_fullStr | Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis |
title_full_unstemmed | Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis |
title_short | Primary Bone Lymphoma of the Shaft of the Tibia, Mimicking Subacute Osteomyelitis |
title_sort | primary bone lymphoma of the shaft of the tibia, mimicking subacute osteomyelitis |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208550/ https://www.ncbi.nlm.nih.gov/pubmed/37234139 http://dx.doi.org/10.7759/cureus.38070 |
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