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Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis

Degradation of defective mitochondria is an essential process to maintain cellular homeostasis and it is strictly regulated by the ubiquitin-proteasome system (UPS) and lysosomal activities. Here, using genome-wide CRISPR and small interference RNA screens, we identified a critical contribution of t...

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Detalles Bibliográficos
Autores principales:	Quarato, Giovanni, Mari, Luigi, Barrows, Nicholas J., Yang, Mao, Ruehl, Sebastian, Chen, Mark J., Guy, Cliff S., Low, Jonathan, Chen, Taosheng, Green, Douglas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208567/ https://www.ncbi.nlm.nih.gov/pubmed/37224250 http://dx.doi.org/10.1126/sciadv.adg8156

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