Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation

Calcins are peptides from scorpion venom with the unique ability to cross cell membranes, gaining access to intracellular targets. Ryanodine Receptors (RyR) are intracellular ion channels that control release of Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Calcins target RyRs and induce l...

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Detalles Bibliográficos
Autores principales: Haji-Ghassemi, Omid, Chen, Yu Seby, Woll, Kellie, Gurrola, Georgina B., Valdivia, Carmen R., Cai, Wenxuan, Li, Songhua, Valdivia, Hector H., Van Petegem, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208580/
https://www.ncbi.nlm.nih.gov/pubmed/37224245
http://dx.doi.org/10.1126/sciadv.adf4936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208580/
https://www.ncbi.nlm.nih.gov/pubmed/37224245
http://dx.doi.org/10.1126/sciadv.adf4936

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