Cargando…

Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents

Several antibody therapeutics have been developed against SARS-CoV-2; however, they have attenuated neutralizing ability against variants. In this study, we generated multiple broadly neutralizing antibodies from B cells of convalescents, by using two types of receptor-binding domains, Wuhan strain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takeshita, Masaru, Fukuyama, Hidehiro, Kamada, Katsuhiko, Matsumoto, Takehisa, Makino-Okamura, Chieko, Lin, Qingshun, Sakuma, Machie, Kawahara, Eiki, Yamazaki, Isato, Uchikubo-Kamo, Tomomi, Tomabechi, Yuri, Hanada, Kazuharu, Hisano, Tamao, Moriyama, Saya, Takahashi, Yoshimasa, Ito, Mutsumi, Imai, Masaki, Maemura, Tadashi, Furusawa, Yuri, Yamayoshi, Seiya, Kawaoka, Yoshihiro, Shirouzu, Mikako, Ishii, Makoto, Saya, Hideyuki, Kondo, Yasushi, Kaneko, Yuko, Suzuki, Katsuya, Fukunaga, Koichi, Takeuchi, Tsutomu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208659/ https://www.ncbi.nlm.nih.gov/pubmed/37288342 http://dx.doi.org/10.1016/j.isci.2023.106955

Ejemplares similares

Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models
por: Takeshita, Masaru, et al.
Publicado: (2022)

Crystal Structure of an Archaeal Tyrosyl-tRNA Synthetase Bound to Photocaged L-Tyrosine and Its Potential Application to Time-Resolved X-ray Crystallography
por: Hosaka, Toshiaki, et al.
Publicado: (2022)

The accuracy of reverse genetics systems for SARS‐CoV‐2: Circular polymerase extension reaction versus bacterial artificial chromosome
por: Furusawa, Yuri, et al.
Publicado: (2023)

A 265-Nanometer High-Power Deep-UV Light-Emitting Diode Rapidly Inactivates SARS-CoV-2 Aerosols
por: Ueki, Hiroshi, et al.
Publicado: (2022)

Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex
por: Kukimoto-Niino, Mutsuko, et al.
Publicado: (2021)

Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca(2+)-binding photoprotein aequorin
por: Inouye, Satoshi, et al.
Publicado: (2021)

Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation
por: Shoji, Shisako, et al.
Publicado: (2017)

Treatment of Highly Pathogenic H7N9 Virus-Infected Mice with Baloxavir Marboxil
por: Kiso, Maki, et al.
Publicado: (2019)

Structural basis for heme detoxification by an ATP-binding cassette–type efflux pump in gram-positive pathogenic bacteria
por: Nakamura, Hiro, et al.
Publicado: (2022)

Epigenetic mechanisms to propagate histone acetylation by p300/CBP
por: Kikuchi, Masaki, et al.
Publicado: (2023)

In vitro and in vivo characterization of SARS-CoV-2 strains resistant to nirmatrelvir
por: Kiso, Maki, et al.
Publicado: (2023)

Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs
por: Shigematsu, Hideki, et al.
Publicado: (2018)

Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope
por: Makabe, Koki, et al.
Publicado: (2021)

Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate
por: Inouye, Satoshi, et al.
Publicado: (2022)

High Levels of miR-483-3p Are Present in Serum Exosomes Upon Infection of Mice With Highly Pathogenic Avian Influenza Virus
por: Maemura, Tadashi, et al.
Publicado: (2020)

Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles
por: Kikuchi, Masaki, et al.
Publicado: (2022)

In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamsters
por: Furusawa, Yuri, et al.
Publicado: (2023)

In vitro and in vivo characterization of SARS-CoV-2 resistance to ensitrelvir
por: Kiso, Maki, et al.
Publicado: (2023)

Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis
por: Kimura‐Someya, Tomomi, et al.
Publicado: (2022)

Targeting Ras-binding domain of ELMO1 by computational nanobody design
por: Tam, Chunlai, et al.
Publicado: (2023)

Structural basis for CRMP2-induced axonal microtubule formation
por: Niwa, Shinsuke, et al.
Publicado: (2017)

Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA
por: Furusawa, Yuri, et al.
Publicado: (2018)

Crystal structures of the S6K1 kinase domain in complexes with inhibitors
por: Niwa, Hideaki, et al.
Publicado: (2014)

Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages
por: Maemura, Tadashi, et al.
Publicado: (2021)

Non-propagative human parainfluenza virus type 2 nasal vaccine robustly protects the upper and lower airways against SARS-CoV-2
por: Ohtsuka, Junpei, et al.
Publicado: (2021)

Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
por: Yamayoshi, Seiya, et al.
Publicado: (2018)

Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses
por: Yasuhara, Atsuhiro, et al.
Publicado: (2018)

Subclade 2.2.1-Specific Human Monoclonal Antibodies That Recognize an Epitope in Antigenic Site A of Influenza A(H5) Virus HA Detected between 2015 and 2018
por: Okuda, Moe, et al.
Publicado: (2019)

Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB
por: Uraki, Ryuta, et al.
Publicado: (2023)

Characterization of Mouse Monoclonal Antibodies Against the HA of A(H7N9) Influenza Virus
por: Ito, Mutsumi, et al.
Publicado: (2019)

Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene
por: Wu, Nicholas C., et al.
Publicado: (2018)

There are no three physiological narrowings in the upper urinary tract: a new concept of the retroperitoneal anatomy around the ureter
por: Kamo, Minobu, et al.
Publicado: (2021)

Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells
por: Terasawa, Kazue, et al.
Publicado: (2021)

Antiviral and bivalent vaccine efficacy against an omicron XBB.1.5 isolate
por: Uraki, Ryuta, et al.
Publicado: (2023)

Efficacy of antivirals and bivalent mRNA vaccines against SARS-CoV-2 isolate CH.1.1
por: Uraki, Ryuta, et al.
Publicado: (2023)

Transmission and re-infection of Omicron variant XBB.1.5 in hamsters
por: Halfmann, Peter J., et al.
Publicado: (2023)

Protein stabilization utilizing a redefined codon
por: Ohtake, Kazumasa, et al.
Publicado: (2015)

Strain-Specific Contribution of Eukaryotic Elongation Factor 1 Gamma to the Translation of Influenza A Virus Proteins
por: Sammaibashi, Shuhei, et al.
Publicado: (2018)

Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity
por: Oishi, Kohei, et al.
Publicado: (2019)

Triple combination therapy of favipiravir plus two monoclonal antibodies eradicates influenza virus from nude mice
por: Kiso, Maki, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1r29nc29vr5ph31cqdt1659ffk