Light-triggered cardiac microphysiological model

Light is recognized as an accurate and noninvasive tool for stimulating excitable cells. Here, we report on a non-genetic approach based on organic molecular phototransducers that allows wiring- and electrode-free tissue modulation. As a proof of concept, we show photostimulation of an in vitro card...

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Detalles Bibliográficos
Autores principales: Vurro, V., Shani, K., Ardoña, H. A. M., Zimmerman, J. F., Sesti, V., Lee, K. Y., Jin, Q., Bertarelli, C., Parker, K. K., Lanzani, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208677/
https://www.ncbi.nlm.nih.gov/pubmed/37234844
http://dx.doi.org/10.1063/5.0143409
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author Vurro, V.
Shani, K.
Ardoña, H. A. M.
Zimmerman, J. F.
Sesti, V.
Lee, K. Y.
Jin, Q.
Bertarelli, C.
Parker, K. K.
Lanzani, G.
author_facet Vurro, V.
Shani, K.
Ardoña, H. A. M.
Zimmerman, J. F.
Sesti, V.
Lee, K. Y.
Jin, Q.
Bertarelli, C.
Parker, K. K.
Lanzani, G.
author_sort Vurro, V.
collection PubMed
description Light is recognized as an accurate and noninvasive tool for stimulating excitable cells. Here, we report on a non-genetic approach based on organic molecular phototransducers that allows wiring- and electrode-free tissue modulation. As a proof of concept, we show photostimulation of an in vitro cardiac microphysiological model mediated by an amphiphilic azobenzene compound that preferentially dwells in the cell membrane. Exploiting this optical based stimulation technology could be a disruptive approach for highly resolved cardiac tissue stimulation.
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spelling pubmed-102086772023-05-25 Light-triggered cardiac microphysiological model Vurro, V. Shani, K. Ardoña, H. A. M. Zimmerman, J. F. Sesti, V. Lee, K. Y. Jin, Q. Bertarelli, C. Parker, K. K. Lanzani, G. APL Bioeng Articles Light is recognized as an accurate and noninvasive tool for stimulating excitable cells. Here, we report on a non-genetic approach based on organic molecular phototransducers that allows wiring- and electrode-free tissue modulation. As a proof of concept, we show photostimulation of an in vitro cardiac microphysiological model mediated by an amphiphilic azobenzene compound that preferentially dwells in the cell membrane. Exploiting this optical based stimulation technology could be a disruptive approach for highly resolved cardiac tissue stimulation. AIP Publishing LLC 2023-05-23 /pmc/articles/PMC10208677/ /pubmed/37234844 http://dx.doi.org/10.1063/5.0143409 Text en © 2023 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Articles
Vurro, V.
Shani, K.
Ardoña, H. A. M.
Zimmerman, J. F.
Sesti, V.
Lee, K. Y.
Jin, Q.
Bertarelli, C.
Parker, K. K.
Lanzani, G.
Light-triggered cardiac microphysiological model
title Light-triggered cardiac microphysiological model
title_full Light-triggered cardiac microphysiological model
title_fullStr Light-triggered cardiac microphysiological model
title_full_unstemmed Light-triggered cardiac microphysiological model
title_short Light-triggered cardiac microphysiological model
title_sort light-triggered cardiac microphysiological model
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208677/
https://www.ncbi.nlm.nih.gov/pubmed/37234844
http://dx.doi.org/10.1063/5.0143409
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