Gastric Carcinoma With Sebaceous Differentiation and SALL4 Expression

A sebaceous carcinoma is rarely seen in extracutaneous sites. We present a 75-year-old man who was admitted with epigastralgia and melena. Endoscopic examination revealed an ulcer on the posterior wall of the gastric antrum, and distal gastrectomy was performed. Histopathological examination reveale...

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Autores principales: Nakanishi, Takaaki, Akita, Masayuki, Ichikawa, Chihiro, Kaneda, Kunihiko, Tamura, Isamu, Kawata, Yumiko, Takahashi, Masayuki, Imai, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208691/
https://www.ncbi.nlm.nih.gov/pubmed/37235001
http://dx.doi.org/10.14309/crj.0000000000001061
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author Nakanishi, Takaaki
Akita, Masayuki
Ichikawa, Chihiro
Kaneda, Kunihiko
Tamura, Isamu
Kawata, Yumiko
Takahashi, Masayuki
Imai, Yukihiro
author_facet Nakanishi, Takaaki
Akita, Masayuki
Ichikawa, Chihiro
Kaneda, Kunihiko
Tamura, Isamu
Kawata, Yumiko
Takahashi, Masayuki
Imai, Yukihiro
author_sort Nakanishi, Takaaki
collection PubMed
description A sebaceous carcinoma is rarely seen in extracutaneous sites. We present a 75-year-old man who was admitted with epigastralgia and melena. Endoscopic examination revealed an ulcer on the posterior wall of the gastric antrum, and distal gastrectomy was performed. Histopathological examination revealed thin to thick trabeculae of polygonal cells with scattered foci of foamy cells, whereas Sudan 3 staining showed lipid vacuoles. Immunohistochemistry was positive for both p40 and SALL4. After considering these findings, we suggest sebaceous differentiation as the diagnosis. To the best of our knowledge, this is the first case of gastric carcinoma with sebaceous differentiation.
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spelling pubmed-102086912023-05-25 Gastric Carcinoma With Sebaceous Differentiation and SALL4 Expression Nakanishi, Takaaki Akita, Masayuki Ichikawa, Chihiro Kaneda, Kunihiko Tamura, Isamu Kawata, Yumiko Takahashi, Masayuki Imai, Yukihiro ACG Case Rep J Case Report A sebaceous carcinoma is rarely seen in extracutaneous sites. We present a 75-year-old man who was admitted with epigastralgia and melena. Endoscopic examination revealed an ulcer on the posterior wall of the gastric antrum, and distal gastrectomy was performed. Histopathological examination revealed thin to thick trabeculae of polygonal cells with scattered foci of foamy cells, whereas Sudan 3 staining showed lipid vacuoles. Immunohistochemistry was positive for both p40 and SALL4. After considering these findings, we suggest sebaceous differentiation as the diagnosis. To the best of our knowledge, this is the first case of gastric carcinoma with sebaceous differentiation. Wolters Kluwer 2023-05-24 /pmc/articles/PMC10208691/ /pubmed/37235001 http://dx.doi.org/10.14309/crj.0000000000001061 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Nakanishi, Takaaki
Akita, Masayuki
Ichikawa, Chihiro
Kaneda, Kunihiko
Tamura, Isamu
Kawata, Yumiko
Takahashi, Masayuki
Imai, Yukihiro
Gastric Carcinoma With Sebaceous Differentiation and SALL4 Expression
title Gastric Carcinoma With Sebaceous Differentiation and SALL4 Expression
title_full Gastric Carcinoma With Sebaceous Differentiation and SALL4 Expression
title_fullStr Gastric Carcinoma With Sebaceous Differentiation and SALL4 Expression
title_full_unstemmed Gastric Carcinoma With Sebaceous Differentiation and SALL4 Expression
title_short Gastric Carcinoma With Sebaceous Differentiation and SALL4 Expression
title_sort gastric carcinoma with sebaceous differentiation and sall4 expression
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208691/
https://www.ncbi.nlm.nih.gov/pubmed/37235001
http://dx.doi.org/10.14309/crj.0000000000001061
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