Cargando…

Adipose tissue insulin resistance exacerbates liver inflammation and fibrosis in a diet-induced NASH model

Insulin regulates various biological processes in adipocytes, and adipose tissue dysfunction due to insulin resistance in this tissue plays a central role in the development of metabolic diseases, including NAFLD and NASH. However, the combined impact of adipose tissue insulin resistance and dietary...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hosokawa, Yusei, Hosooka, Tetsuya, Imamori, Makoto, Yamaguchi, Kanji, Itoh, Yoshito, Ogawa, Wataru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208706/ https://www.ncbi.nlm.nih.gov/pubmed/37219877 http://dx.doi.org/10.1097/HC9.0000000000000161

Ejemplares similares

A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells
por: Kasahara, Nanaho, et al.
Publicado: (2023)

Kruppel‐like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes
por: Nabatame, Yuko, et al.
Publicado: (2021)

SGLT2 inhibitors for genetic and acquired insulin resistance: Considerations for clinical use
por: Hosokawa, Yusei, et al.
Publicado: (2020)

A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis
por: Hosooka, Tetsuya, et al.
Publicado: (2015)

Vascular endothelial growth factor‐B as a therapeutic target to prevent ectopic fat deposition
por: Hosooka, Tetsuya, et al.
Publicado: (2013)

Production, Exacerbating Effect, and EV-Mediated Transcription of Hepatic CCN2 in NASH: Implications for Diagnosis and Therapy of NASH Fibrosis
por: Li, Xinlei, et al.
Publicado: (2023)

Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
por: Kanagaki, Shuhei, et al.
Publicado: (2023)

PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat
por: Okishio, Shinya, et al.
Publicado: (2020)

Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation
por: Nagasaki, Atsuhiro, et al.
Publicado: (2020)

Aging-associated impairment in metabolic compensation by subcutaneous adipose tissue promotes diet-induced fatty liver disease in mice
por: Taketani, Hiroyoshi, et al.
Publicado: (2019)

Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH
por: Kanamori, Yohei, et al.
Publicado: (2021)

Dietary Cholic Acid Exacerbates Liver Fibrosis in NASH Model of Sprague–Dawley Rats Fed a High-Fat and High-Cholesterol Diet
por: Ichimura-Shimizu, Mayuko, et al.
Publicado: (2022)

E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9
por: Rodrigues, Robim M., et al.
Publicado: (2021)

Systemic and adipose tissue inflammation in NASH: correlations with histopathological aspects
por: Micu, Elena Simona, et al.
Publicado: (2021)

Imaging biomarkers of NAFLD, NASH, and fibrosis
por: Ajmera, Veeral, et al.
Publicado: (2021)

Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH
por: Itoh, Michiko, et al.
Publicado: (2023)

NASH-inducing Diets in Göttingen Minipigs
por: Pedersen, Henrik D., et al.
Publicado: (2020)

Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH
por: Shiba, Kumiko, et al.
Publicado: (2018)

CD4(+) T cell activation and inflammation in NASH-related fibrosis
por: Zhou, Yunfeng, et al.
Publicado: (2022)

MSC−sEV Treatment Polarizes Pro−Fibrotic M2 Macrophages without Exacerbating Liver Fibrosis in NASH
por: Zhang, Bin, et al.
Publicado: (2023)

Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors
por: Traber, Peter G., et al.
Publicado: (2013)

BET Inhibition Improves NASH and Liver Fibrosis
por: Middleton, Sarah A., et al.
Publicado: (2018)

Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load
por: Kuramoto, Naoki, et al.
Publicado: (2021)

Diet and exercise in NAFLD/NASH: Beyond the obvious
por: Semmler, Georg, et al.
Publicado: (2021)

Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance
por: Ma, Xiaojun, et al.
Publicado: (2017)

MerTK, a risk factor for NASH fibrosis
por: Wang, Xiaobo, et al.
Publicado: (2020)

Editorial: Noninvasive Fibrosis Biomarkers in Patients With NASH With Diabetes
por: Fan, Weiguo, et al.
Publicado: (2021)

Comparison of portal vein hemodynamics with ultrasound-based elastography for the prediction of liver fibrosis in patients with chronic liver disease
por: Yamaguchi, Kanji, et al.
Publicado: (2023)

Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model
por: van Koppen, Arianne, et al.
Publicado: (2017)

A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue
por: de Almeida Faria, Juliana, et al.
Publicado: (2017)

Acute exacerbation of idiopathic pulmonary fibrosis induced by pertussis: the first case report
por: Hirai, Kuniaki, et al.
Publicado: (2019)

Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH
por: Kang, Gideon G., et al.
Publicado: (2022)

Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers
por: Kisoh, Keishi, et al.
Publicado: (2021)

Experimental and Investigational Targeted Therapies for the Management of Fibrosis in NASH: An Update
por: Huisman, Tsipora M, et al.
Publicado: (2021)

The role of oxidized lipid species in insulin resistance and NASH in children
por: Santoro, Nicola, et al.
Publicado: (2022)

The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH)
por: Drescher, Hannah K., et al.
Publicado: (2019)

Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats
por: Watanabe, Yukari, et al.
Publicado: (2023)

The Role of the Histone Methyltransferase EZH2 in Liver Inflammation and Fibrosis in STAM NASH Mice
por: Lee, Seul, et al.
Publicado: (2020)

High-fat Western diet consumption exacerbates silica-induced pulmonary inflammation and fibrosis
por: Thompson, Janet A., et al.
Publicado: (2022)

The Appropriate Opportunity for Evaluating Liver Fibrosis by Using the FIB-4 Index in Patients with Nonalcoholic Fatty Liver Disease in Japan
por: Seko, Yuya, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ei8o91dasmhn72d14stb70ki83