Cargando…

Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor–deficient mice

HCC is the most common primary liver cancer and a leading cause of cancer-related mortality. Gut microbiota is a large collection of microbes, predominately bacteria, that harbor the gastrointestinal tract. Changes in gut microbiota that deviate from the native composition, that is, “dysbiosis,” is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Golonka, Rachel M., Yeoh, Beng San, Saha, Piu, Gohara, Amira, Tummala, Ramakumar, Stepkowski, Stanislaw, Tiwari, Amit K., Joe, Bina, Gonzalez, Frank J., Gewirtz, Andrew T., Vijay-Kumar, Matam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208708/ https://www.ncbi.nlm.nih.gov/pubmed/37219858 http://dx.doi.org/10.1097/HC9.0000000000000166

Ejemplares similares

Bacterial flagellin is a dominant, stable innate immune activator in the gastrointestinal contents of mice and rats
por: Vijay-Kumar, Matam, et al.
Publicado: (2023)

Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice
por: Yeoh, Beng San, et al.
Publicado: (2023)

Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor
por: Bretin, Alexis, et al.
Publicado: (2023)

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy
por: Campbell, Connor, et al.
Publicado: (2023)

PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium
por: Saha, Piu, et al.
Publicado: (2019)

Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains
por: Saha, Piu, et al.
Publicado: (2020)

Enterobactin induces the chemokine, interleukin-8, from intestinal epithelia by chelating intracellular iron
por: Saha, Piu, et al.
Publicado: (2020)

Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis
por: Abokor, Ahmed A., et al.
Publicado: (2021)

Adaptive Immunity Induces Tolerance to Flagellin by Attenuating TLR5 and NLRC4-Mediated Innate Immune Responses
por: Yeoh, Beng San, et al.
Publicado: (2019)

Eat more natural dietary fiber and whole grains to minimize liver disease risk
por: Golonka, Rachel M., et al.
Publicado: (2022)

Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation
por: Saha, Piu, et al.
Publicado: (2016)

Microbiota-Inducible Innate Immune Siderophore Binding Protein Lipocalin 2 Is Critical for Intestinal Homeostasis
por: Singh, Vishal, et al.
Publicado: (2016)

Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort
por: Golonka, Rachel M, et al.
Publicado: (2019)

Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet–Induced Liver Disease
por: Etienne-Mesmin, Lucie, et al.
Publicado: (2016)

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension
por: Chakraborty, Saroj, et al.
Publicado: (2018)

Gut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme Peroxidases
por: Saha, Piu, et al.
Publicado: (2016)

Psyllium fiber protects mice against western diet-induced metabolic syndrome via the gut microbiota-dependent mechanism
por: Bretin, Alexis, et al.
Publicado: (2023)

Pathophysiology of reflux oesophagitis: role of Toll-like receptors 2 and 4 and Farnesoid X receptor
por: Nortunen, Minna, et al.
Publicado: (2021)

Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice
por: Vijay-Kumar, Matam, et al.
Publicado: (2011)

Fermentable fiber-induced hepatocellular carcinoma in mice recapitulates gene signatures found in human liver cancer
por: Chandrashekar, Darshan Shimoga, et al.
Publicado: (2020)

Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites
por: Chakraborty, Saroj, et al.
Publicado: (2023)

“Western Diet”-Induced Adipose Inflammation Requires a Complex Gut Microbiota
por: Tran, Hao Q., et al.
Publicado: (2019)

The Farnesoid X Receptor: Good for BAD
por: Keely, Stephen J., et al.
Publicado: (2016)

Farnesoid X receptor (FXR): Structures and ligands
por: Jiang, Longying, et al.
Publicado: (2021)

TLR5 Activation Induces Secretory Interleukin-1 Receptor Antagonist (sIL-1Ra) and Reduces Inflammasome-associated Tissue Damage
por: Carvalho, Frederic A., et al.
Publicado: (2010)

Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells
por: Kumar, Matam Vijay, et al.
Publicado: (2004)

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model
por: Wang, Xiaoxin X., et al.
Publicado: (2010)

Natural Products Targeting Liver X Receptors or Farnesoid X Receptor
por: She, Jianglian, et al.
Publicado: (2022)

Molecular tuning of farnesoid X receptor partial agonism
por: Merk, Daniel, et al.
Publicado: (2019)

Microbiota-induced obesity requires farnesoid X receptor
por: Parséus, Ava, et al.
Publicado: (2017)

Role of Farnesoid X Receptor in the Pathogenesis of Respiratory Diseases
por: Wu, Jin-nan, et al.
Publicado: (2020)

The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity
por: Rausch, Magdalena, et al.
Publicado: (2022)

Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background
por: Singh, Vishal, et al.
Publicado: (2017)

Invited Perspective: PFOS–Pick Fiber, Oust Sulfonate
por: Golonka, Rachel M., et al.
Publicado: (2022)

Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
por: Li, Guodong, et al.
Publicado: (2015)

Bacterial metabolites directly modulate farnesoid X receptor activity
por: Zhang, Xianqin, et al.
Publicado: (2015)

Allosteric modulation of the farnesoid X receptor by a small molecule
por: Gabler, Matthias, et al.
Publicado: (2018)

Identification of FDA-approved drugs targeting the Farnesoid X Receptor
por: van de Wiel, Sandra M. W., et al.
Publicado: (2019)

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis
por: Li, Hong, et al.
Publicado: (2019)

Farnesoid X Receptor Agonists as Therapeutic Target for Cardiometabolic Diseases
por: Li, Chao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_59a1jebikv9jcbtk2hg5f4ld7b