Cargando…
Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults
While high-resolution manometry (HRM) is widely accepted as a safe procedure, no study has assessed the safety profile of HRM in clinical practice. This study aimed to determine the safety and tolerability of HRM and to investigate potential determinants of intolerability. METHODS: We obtained HRM p...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208713/ https://www.ncbi.nlm.nih.gov/pubmed/36854056 http://dx.doi.org/10.14309/ctg.0000000000000571 |
_version_ | 1785046729137061888 |
---|---|
author | Oh, Janice E. Huang, Lizhou Takakura, Will Khuu, Kevin Wang, Jiajing Kowalewski, Edward Huang, Shao-Chi Chang, Bianca Pimentel, Mark Rezaie, Ali |
author_facet | Oh, Janice E. Huang, Lizhou Takakura, Will Khuu, Kevin Wang, Jiajing Kowalewski, Edward Huang, Shao-Chi Chang, Bianca Pimentel, Mark Rezaie, Ali |
author_sort | Oh, Janice E. |
collection | PubMed |
description | While high-resolution manometry (HRM) is widely accepted as a safe procedure, no study has assessed the safety profile of HRM in clinical practice. This study aimed to determine the safety and tolerability of HRM and to investigate potential determinants of intolerability. METHODS: We obtained HRM procedure reports, demographics, and clinical data (2005–2022) at a tertiary center using electronic chart review. Our primary outcome was HRM tolerability. Multivariable regression was performed to identify associations between the outcome and covariates including age, sex, race, and comorbidities. RESULTS: A total of 5,107 patients (60.3% female) were included. Of them, 5,050 patients (98.9%) tolerated HRM well and 57 patients (1.1%) did not. Age had a statistically significant effect on tolerance: those younger than 18 years had more than a 5-fold increase in not tolerating HRM compared with those aged 18–79 years (5.77% vs 0.99%; odds ratio [OR] = 5.44, 95% confidence interval [CI] 1.60–18.45; P = 0.007), and those aged 80 years or older were also more likely to terminate HRM (2.43% vs 0.99%; OR = 2.56, 95% CI 1.13–5.76; P = 0.024). While prior foregut surgery had a significant effect on tolerance (OR = 8.06, 95% CI 2.29–28.39; P = 0.001), other factors of race, sex, body mass index, and psychological or cognitive disorders had no significant impact. No serious complications were identified. DISCUSSION: HRM is safe and well-tolerated with approximately 1 in every 100 patients being unable to tolerate HRM. Intolerance was more commonly seen in children and seniors due to minor symptoms of discomfort without serious complications. These data points are crucial to counsel patients in whom HRM is being considered. |
format | Online Article Text |
id | pubmed-10208713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-102087132023-05-25 Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults Oh, Janice E. Huang, Lizhou Takakura, Will Khuu, Kevin Wang, Jiajing Kowalewski, Edward Huang, Shao-Chi Chang, Bianca Pimentel, Mark Rezaie, Ali Clin Transl Gastroenterol Article While high-resolution manometry (HRM) is widely accepted as a safe procedure, no study has assessed the safety profile of HRM in clinical practice. This study aimed to determine the safety and tolerability of HRM and to investigate potential determinants of intolerability. METHODS: We obtained HRM procedure reports, demographics, and clinical data (2005–2022) at a tertiary center using electronic chart review. Our primary outcome was HRM tolerability. Multivariable regression was performed to identify associations between the outcome and covariates including age, sex, race, and comorbidities. RESULTS: A total of 5,107 patients (60.3% female) were included. Of them, 5,050 patients (98.9%) tolerated HRM well and 57 patients (1.1%) did not. Age had a statistically significant effect on tolerance: those younger than 18 years had more than a 5-fold increase in not tolerating HRM compared with those aged 18–79 years (5.77% vs 0.99%; odds ratio [OR] = 5.44, 95% confidence interval [CI] 1.60–18.45; P = 0.007), and those aged 80 years or older were also more likely to terminate HRM (2.43% vs 0.99%; OR = 2.56, 95% CI 1.13–5.76; P = 0.024). While prior foregut surgery had a significant effect on tolerance (OR = 8.06, 95% CI 2.29–28.39; P = 0.001), other factors of race, sex, body mass index, and psychological or cognitive disorders had no significant impact. No serious complications were identified. DISCUSSION: HRM is safe and well-tolerated with approximately 1 in every 100 patients being unable to tolerate HRM. Intolerance was more commonly seen in children and seniors due to minor symptoms of discomfort without serious complications. These data points are crucial to counsel patients in whom HRM is being considered. Wolters Kluwer 2023-03-01 /pmc/articles/PMC10208713/ /pubmed/36854056 http://dx.doi.org/10.14309/ctg.0000000000000571 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Article Oh, Janice E. Huang, Lizhou Takakura, Will Khuu, Kevin Wang, Jiajing Kowalewski, Edward Huang, Shao-Chi Chang, Bianca Pimentel, Mark Rezaie, Ali Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults |
title | Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults |
title_full | Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults |
title_fullStr | Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults |
title_full_unstemmed | Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults |
title_short | Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults |
title_sort | safety and tolerability of high-resolution esophageal manometry in children and adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208713/ https://www.ncbi.nlm.nih.gov/pubmed/36854056 http://dx.doi.org/10.14309/ctg.0000000000000571 |
work_keys_str_mv | AT ohjanicee safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults AT huanglizhou safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults AT takakurawill safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults AT khuukevin safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults AT wangjiajing safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults AT kowalewskiedward safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults AT huangshaochi safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults AT changbianca safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults AT pimentelmark safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults AT rezaieali safetyandtolerabilityofhighresolutionesophagealmanometryinchildrenandadults |