Severe Erythroderma Due to Adult-onset Still's Disease-like Disease Related to Graft-versus-host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

A 35-year-old woman was treated with chemotherapy for leukemia. One year later, allogeneic hematopoietic stem cell transplantation (HSCT) was performed with umbilical cord blood. After nine months, she developed a spiking fever, sore throat, arthralgia, pleural effusion, hyperferritinemia, and persi...

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Detalles Bibliográficos
Autores principales: Teramoto-Shibuya, Akiko, Funamizu, Kaoru, Sawa, Naoki, Suenaga, Atsuhiko, Oba, Yuki, Ikuma, Daisuke, Yamanouchi, Masayuki, Hasegawa, Eiko, Sekine, Akinari, Suwabe, Tatsuya, Kono, Kei, Kinowaki, Keiichi, Fujii, Takeshi, Takemura, Tamiko, Hayashi, Nobukazu, Nishida, Aya, Mori, Yuki, Wake, Atsushi, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208780/
https://www.ncbi.nlm.nih.gov/pubmed/37121719
http://dx.doi.org/10.2169/internalmedicine.0316-22
Descripción
Sumario:A 35-year-old woman was treated with chemotherapy for leukemia. One year later, allogeneic hematopoietic stem cell transplantation (HSCT) was performed with umbilical cord blood. After nine months, she developed a spiking fever, sore throat, arthralgia, pleural effusion, hyperferritinemia, and persistent generalized pruritic erythema. A skin biopsy showed dyskeratotic cells in the epidermis, neutrophil infiltration in the epidermis and upper dermis, and neutrophils in the parakeratotic layer. Treatment with tocilizumab was effective. Adult-onset Still's disease (AOSD)-like disease related to graft versus-host disease (GVHD) after HSCT was suspected. Abnormal immune states related to GVHD may cause AOSD-like disease with more severe skin lesions than usual.

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