Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells

A 76-year-old man presented with skin plaque and splenic nodules, and diffuse large B-cell lymphoma (DLBCL) with infiltration of T-cells was suspected based on the skin lesions. The disease showed indolent clinical behavior for three months, when systemic lymphadenopathy rapidly evolved. An inguinal...

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Detalles Bibliográficos
Autores principales: Ishii, Keitaro, Kamachi, Kazuharu, Okamoto, Sho, Katsuya, Hiroo, Fujita, Mai, Nagaie, Toshiaki, Nishioka, Atsujiro, Yoshimura, Mariko, Ureshino, Hiroshi, Kubota, Yasushi, Ando, Toshihiko, Watanabe, Tatsuro, Takeuchi, Mai, Kai, Keita, Ohshima, Koichi, Kimura, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208781/
https://www.ncbi.nlm.nih.gov/pubmed/36130892
http://dx.doi.org/10.2169/internalmedicine.0521-22
Descripción
Sumario:A 76-year-old man presented with skin plaque and splenic nodules, and diffuse large B-cell lymphoma (DLBCL) with infiltration of T-cells was suspected based on the skin lesions. The disease showed indolent clinical behavior for three months, when systemic lymphadenopathy rapidly evolved. An inguinal lymph node biopsy revealed DLBCL with abundant infiltration of T follicular helper (TFH) cells. A polymerase chain reaction-based analysis of immunoglobulin variable heavy chain showed that the skin, splenic nodules, and inguinal lymph node shared the same clone. This case indicates that the dysregulated infiltration of TFH cells in the tumor microenvironment accelerates the lymphomagenesis and progression of DLBCL.

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