Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells

A 76-year-old man presented with skin plaque and splenic nodules, and diffuse large B-cell lymphoma (DLBCL) with infiltration of T-cells was suspected based on the skin lesions. The disease showed indolent clinical behavior for three months, when systemic lymphadenopathy rapidly evolved. An inguinal...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishii, Keitaro, Kamachi, Kazuharu, Okamoto, Sho, Katsuya, Hiroo, Fujita, Mai, Nagaie, Toshiaki, Nishioka, Atsujiro, Yoshimura, Mariko, Ureshino, Hiroshi, Kubota, Yasushi, Ando, Toshihiko, Watanabe, Tatsuro, Takeuchi, Mai, Kai, Keita, Ohshima, Koichi, Kimura, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208781/
https://www.ncbi.nlm.nih.gov/pubmed/36130892
http://dx.doi.org/10.2169/internalmedicine.0521-22
_version_ 1785046742741286912
author Ishii, Keitaro
Kamachi, Kazuharu
Okamoto, Sho
Katsuya, Hiroo
Fujita, Mai
Nagaie, Toshiaki
Nishioka, Atsujiro
Yoshimura, Mariko
Ureshino, Hiroshi
Kubota, Yasushi
Ando, Toshihiko
Watanabe, Tatsuro
Takeuchi, Mai
Kai, Keita
Ohshima, Koichi
Kimura, Shinya
author_facet Ishii, Keitaro
Kamachi, Kazuharu
Okamoto, Sho
Katsuya, Hiroo
Fujita, Mai
Nagaie, Toshiaki
Nishioka, Atsujiro
Yoshimura, Mariko
Ureshino, Hiroshi
Kubota, Yasushi
Ando, Toshihiko
Watanabe, Tatsuro
Takeuchi, Mai
Kai, Keita
Ohshima, Koichi
Kimura, Shinya
author_sort Ishii, Keitaro
collection PubMed
description A 76-year-old man presented with skin plaque and splenic nodules, and diffuse large B-cell lymphoma (DLBCL) with infiltration of T-cells was suspected based on the skin lesions. The disease showed indolent clinical behavior for three months, when systemic lymphadenopathy rapidly evolved. An inguinal lymph node biopsy revealed DLBCL with abundant infiltration of T follicular helper (TFH) cells. A polymerase chain reaction-based analysis of immunoglobulin variable heavy chain showed that the skin, splenic nodules, and inguinal lymph node shared the same clone. This case indicates that the dysregulated infiltration of TFH cells in the tumor microenvironment accelerates the lymphomagenesis and progression of DLBCL.
format Online
Article
Text
id pubmed-10208781
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-102087812023-05-25 Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells Ishii, Keitaro Kamachi, Kazuharu Okamoto, Sho Katsuya, Hiroo Fujita, Mai Nagaie, Toshiaki Nishioka, Atsujiro Yoshimura, Mariko Ureshino, Hiroshi Kubota, Yasushi Ando, Toshihiko Watanabe, Tatsuro Takeuchi, Mai Kai, Keita Ohshima, Koichi Kimura, Shinya Intern Med Case Report A 76-year-old man presented with skin plaque and splenic nodules, and diffuse large B-cell lymphoma (DLBCL) with infiltration of T-cells was suspected based on the skin lesions. The disease showed indolent clinical behavior for three months, when systemic lymphadenopathy rapidly evolved. An inguinal lymph node biopsy revealed DLBCL with abundant infiltration of T follicular helper (TFH) cells. A polymerase chain reaction-based analysis of immunoglobulin variable heavy chain showed that the skin, splenic nodules, and inguinal lymph node shared the same clone. This case indicates that the dysregulated infiltration of TFH cells in the tumor microenvironment accelerates the lymphomagenesis and progression of DLBCL. The Japanese Society of Internal Medicine 2022-09-21 2023-05-01 /pmc/articles/PMC10208781/ /pubmed/36130892 http://dx.doi.org/10.2169/internalmedicine.0521-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ishii, Keitaro
Kamachi, Kazuharu
Okamoto, Sho
Katsuya, Hiroo
Fujita, Mai
Nagaie, Toshiaki
Nishioka, Atsujiro
Yoshimura, Mariko
Ureshino, Hiroshi
Kubota, Yasushi
Ando, Toshihiko
Watanabe, Tatsuro
Takeuchi, Mai
Kai, Keita
Ohshima, Koichi
Kimura, Shinya
Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells
title Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells
title_full Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells
title_fullStr Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells
title_full_unstemmed Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells
title_short Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells
title_sort diffuse large b-cell lymphoma involving an abundant infiltration of t follicular helper cells
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208781/
https://www.ncbi.nlm.nih.gov/pubmed/36130892
http://dx.doi.org/10.2169/internalmedicine.0521-22
work_keys_str_mv AT ishiikeitaro diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT kamachikazuharu diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT okamotosho diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT katsuyahiroo diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT fujitamai diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT nagaietoshiaki diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT nishiokaatsujiro diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT yoshimuramariko diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT ureshinohiroshi diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT kubotayasushi diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT andotoshihiko diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT watanabetatsuro diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT takeuchimai diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT kaikeita diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT ohshimakoichi diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells
AT kimurashinya diffuselargebcelllymphomainvolvinganabundantinfiltrationoftfollicularhelpercells

Ejemplares similares