The topoisomerase inhibitor CPT-11 prevents the growth and metastasis of lung cancer cells in nude mice by inhibiting EGFR/MAPK signaling pathway

OBJECTIVE: The topoisomerase inhibitor CPT-11 has been applied in treatment of multiple cancer types. Here, we probed into the possible mechanism of CPT-11 in affecting growth and metastasis of lung cancer (LC) cells, with involvement of the EGFR/MAPK pathway. METHODS: The target protein of CPT-11 w...

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Detalles Bibliográficos
Autores principales: Yin, Yingqiu, Xie, Junling, Peng, Feng, Tan, Liming, Xiao, Yun, Zheng, Huiying, Yin, Lingzhi, Situ, Huijing, Zhang, Shanqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208938/
https://www.ncbi.nlm.nih.gov/pubmed/37251857
http://dx.doi.org/10.1016/j.heliyon.2023.e15805

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