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Plasma proteins related to inflammatory diet predict future cognitive impairment

Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma...

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Autores principales: Duggan, Michael R., Butler, Lauren, Peng, Zhongsheng, Daya, Gulzar N., Moghekar, Abhay, An, Yang, Rapp, Stephen R., Hayden, Kathleen M., Shadyab, Aladdin H., Natale, Ginny, Liu, Longjian, Snetselaar, Linda, Moaddel, Ruin, Rebholz, Casey M., Sullivan, Kevin, Ballantyne, Christie M., Resnick, Susan M., Ferrucci, Luigi, Walker, Keenan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208977/
https://www.ncbi.nlm.nih.gov/pubmed/36737481
http://dx.doi.org/10.1038/s41380-023-01975-7
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author Duggan, Michael R.
Butler, Lauren
Peng, Zhongsheng
Daya, Gulzar N.
Moghekar, Abhay
An, Yang
Rapp, Stephen R.
Hayden, Kathleen M.
Shadyab, Aladdin H.
Natale, Ginny
Liu, Longjian
Snetselaar, Linda
Moaddel, Ruin
Rebholz, Casey M.
Sullivan, Kevin
Ballantyne, Christie M.
Resnick, Susan M.
Ferrucci, Luigi
Walker, Keenan A.
author_facet Duggan, Michael R.
Butler, Lauren
Peng, Zhongsheng
Daya, Gulzar N.
Moghekar, Abhay
An, Yang
Rapp, Stephen R.
Hayden, Kathleen M.
Shadyab, Aladdin H.
Natale, Ginny
Liu, Longjian
Snetselaar, Linda
Moaddel, Ruin
Rebholz, Casey M.
Sullivan, Kevin
Ballantyne, Christie M.
Resnick, Susan M.
Ferrucci, Luigi
Walker, Keenan A.
author_sort Duggan, Michael R.
collection PubMed
description Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women’s Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8] years). Results provide insights into how inflammatory nutritional patterns are associated with an immune-related proteome and identify a group of proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3, ITGA11) related to future cognitive impairment over a 14-year follow-up period. Several of these inflammatory diet proteins were also associated with dementia risk across two external cohorts (ARIC, ESTHER), correlated with plasma biomarkers of Alzheimer’s disease (AD) pathology (Aβ(42/40)) and/or neurodegeneration (NfL), and related to an MRI-defined index of neurodegenerative brain atrophy in a separate cohort (BLSA). In addition to evaluating their biological relevance, assessing their potential role in AD, and characterizing their immune-tissue/cell-specific expression, we leveraged published RNA-seq results to examine how the in vitro regulation of genes encoding these candidate proteins might be altered in response to an immune challenge. Our findings indicate how dietary patterns with higher inflammatory potential relate to plasma levels of immunologically relevant proteins and highlight the molecular mediators which predict subsequent risk for age-related cognitive impairment.
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spelling pubmed-102089772023-05-26 Plasma proteins related to inflammatory diet predict future cognitive impairment Duggan, Michael R. Butler, Lauren Peng, Zhongsheng Daya, Gulzar N. Moghekar, Abhay An, Yang Rapp, Stephen R. Hayden, Kathleen M. Shadyab, Aladdin H. Natale, Ginny Liu, Longjian Snetselaar, Linda Moaddel, Ruin Rebholz, Casey M. Sullivan, Kevin Ballantyne, Christie M. Resnick, Susan M. Ferrucci, Luigi Walker, Keenan A. Mol Psychiatry Article Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women’s Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8] years). Results provide insights into how inflammatory nutritional patterns are associated with an immune-related proteome and identify a group of proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3, ITGA11) related to future cognitive impairment over a 14-year follow-up period. Several of these inflammatory diet proteins were also associated with dementia risk across two external cohorts (ARIC, ESTHER), correlated with plasma biomarkers of Alzheimer’s disease (AD) pathology (Aβ(42/40)) and/or neurodegeneration (NfL), and related to an MRI-defined index of neurodegenerative brain atrophy in a separate cohort (BLSA). In addition to evaluating their biological relevance, assessing their potential role in AD, and characterizing their immune-tissue/cell-specific expression, we leveraged published RNA-seq results to examine how the in vitro regulation of genes encoding these candidate proteins might be altered in response to an immune challenge. Our findings indicate how dietary patterns with higher inflammatory potential relate to plasma levels of immunologically relevant proteins and highlight the molecular mediators which predict subsequent risk for age-related cognitive impairment. Nature Publishing Group UK 2023-02-03 2023 /pmc/articles/PMC10208977/ /pubmed/36737481 http://dx.doi.org/10.1038/s41380-023-01975-7 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Duggan, Michael R.
Butler, Lauren
Peng, Zhongsheng
Daya, Gulzar N.
Moghekar, Abhay
An, Yang
Rapp, Stephen R.
Hayden, Kathleen M.
Shadyab, Aladdin H.
Natale, Ginny
Liu, Longjian
Snetselaar, Linda
Moaddel, Ruin
Rebholz, Casey M.
Sullivan, Kevin
Ballantyne, Christie M.
Resnick, Susan M.
Ferrucci, Luigi
Walker, Keenan A.
Plasma proteins related to inflammatory diet predict future cognitive impairment
title Plasma proteins related to inflammatory diet predict future cognitive impairment
title_full Plasma proteins related to inflammatory diet predict future cognitive impairment
title_fullStr Plasma proteins related to inflammatory diet predict future cognitive impairment
title_full_unstemmed Plasma proteins related to inflammatory diet predict future cognitive impairment
title_short Plasma proteins related to inflammatory diet predict future cognitive impairment
title_sort plasma proteins related to inflammatory diet predict future cognitive impairment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208977/
https://www.ncbi.nlm.nih.gov/pubmed/36737481
http://dx.doi.org/10.1038/s41380-023-01975-7
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