Cargando…
Plasma proteins related to inflammatory diet predict future cognitive impairment
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208977/ https://www.ncbi.nlm.nih.gov/pubmed/36737481 http://dx.doi.org/10.1038/s41380-023-01975-7 |
_version_ | 1785046784607780864 |
---|---|
author | Duggan, Michael R. Butler, Lauren Peng, Zhongsheng Daya, Gulzar N. Moghekar, Abhay An, Yang Rapp, Stephen R. Hayden, Kathleen M. Shadyab, Aladdin H. Natale, Ginny Liu, Longjian Snetselaar, Linda Moaddel, Ruin Rebholz, Casey M. Sullivan, Kevin Ballantyne, Christie M. Resnick, Susan M. Ferrucci, Luigi Walker, Keenan A. |
author_facet | Duggan, Michael R. Butler, Lauren Peng, Zhongsheng Daya, Gulzar N. Moghekar, Abhay An, Yang Rapp, Stephen R. Hayden, Kathleen M. Shadyab, Aladdin H. Natale, Ginny Liu, Longjian Snetselaar, Linda Moaddel, Ruin Rebholz, Casey M. Sullivan, Kevin Ballantyne, Christie M. Resnick, Susan M. Ferrucci, Luigi Walker, Keenan A. |
author_sort | Duggan, Michael R. |
collection | PubMed |
description | Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women’s Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8] years). Results provide insights into how inflammatory nutritional patterns are associated with an immune-related proteome and identify a group of proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3, ITGA11) related to future cognitive impairment over a 14-year follow-up period. Several of these inflammatory diet proteins were also associated with dementia risk across two external cohorts (ARIC, ESTHER), correlated with plasma biomarkers of Alzheimer’s disease (AD) pathology (Aβ(42/40)) and/or neurodegeneration (NfL), and related to an MRI-defined index of neurodegenerative brain atrophy in a separate cohort (BLSA). In addition to evaluating their biological relevance, assessing their potential role in AD, and characterizing their immune-tissue/cell-specific expression, we leveraged published RNA-seq results to examine how the in vitro regulation of genes encoding these candidate proteins might be altered in response to an immune challenge. Our findings indicate how dietary patterns with higher inflammatory potential relate to plasma levels of immunologically relevant proteins and highlight the molecular mediators which predict subsequent risk for age-related cognitive impairment. |
format | Online Article Text |
id | pubmed-10208977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102089772023-05-26 Plasma proteins related to inflammatory diet predict future cognitive impairment Duggan, Michael R. Butler, Lauren Peng, Zhongsheng Daya, Gulzar N. Moghekar, Abhay An, Yang Rapp, Stephen R. Hayden, Kathleen M. Shadyab, Aladdin H. Natale, Ginny Liu, Longjian Snetselaar, Linda Moaddel, Ruin Rebholz, Casey M. Sullivan, Kevin Ballantyne, Christie M. Resnick, Susan M. Ferrucci, Luigi Walker, Keenan A. Mol Psychiatry Article Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women’s Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8] years). Results provide insights into how inflammatory nutritional patterns are associated with an immune-related proteome and identify a group of proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3, ITGA11) related to future cognitive impairment over a 14-year follow-up period. Several of these inflammatory diet proteins were also associated with dementia risk across two external cohorts (ARIC, ESTHER), correlated with plasma biomarkers of Alzheimer’s disease (AD) pathology (Aβ(42/40)) and/or neurodegeneration (NfL), and related to an MRI-defined index of neurodegenerative brain atrophy in a separate cohort (BLSA). In addition to evaluating their biological relevance, assessing their potential role in AD, and characterizing their immune-tissue/cell-specific expression, we leveraged published RNA-seq results to examine how the in vitro regulation of genes encoding these candidate proteins might be altered in response to an immune challenge. Our findings indicate how dietary patterns with higher inflammatory potential relate to plasma levels of immunologically relevant proteins and highlight the molecular mediators which predict subsequent risk for age-related cognitive impairment. Nature Publishing Group UK 2023-02-03 2023 /pmc/articles/PMC10208977/ /pubmed/36737481 http://dx.doi.org/10.1038/s41380-023-01975-7 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Duggan, Michael R. Butler, Lauren Peng, Zhongsheng Daya, Gulzar N. Moghekar, Abhay An, Yang Rapp, Stephen R. Hayden, Kathleen M. Shadyab, Aladdin H. Natale, Ginny Liu, Longjian Snetselaar, Linda Moaddel, Ruin Rebholz, Casey M. Sullivan, Kevin Ballantyne, Christie M. Resnick, Susan M. Ferrucci, Luigi Walker, Keenan A. Plasma proteins related to inflammatory diet predict future cognitive impairment |
title | Plasma proteins related to inflammatory diet predict future cognitive impairment |
title_full | Plasma proteins related to inflammatory diet predict future cognitive impairment |
title_fullStr | Plasma proteins related to inflammatory diet predict future cognitive impairment |
title_full_unstemmed | Plasma proteins related to inflammatory diet predict future cognitive impairment |
title_short | Plasma proteins related to inflammatory diet predict future cognitive impairment |
title_sort | plasma proteins related to inflammatory diet predict future cognitive impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208977/ https://www.ncbi.nlm.nih.gov/pubmed/36737481 http://dx.doi.org/10.1038/s41380-023-01975-7 |
work_keys_str_mv | AT dugganmichaelr plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT butlerlauren plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT pengzhongsheng plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT dayagulzarn plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT moghekarabhay plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT anyang plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT rappstephenr plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT haydenkathleenm plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT shadyabaladdinh plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT nataleginny plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT liulongjian plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT snetselaarlinda plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT moaddelruin plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT rebholzcaseym plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT sullivankevin plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT ballantynechristiem plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT resnicksusanm plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT ferrucciluigi plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment AT walkerkeenana plasmaproteinsrelatedtoinflammatorydietpredictfuturecognitiveimpairment |