Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule

Dysregulated neurite outgrowth and synapse formation underlie many psychiatric disorders, which are also manifested by wolfram syndrome (WS). Whether and how the causative gene WFS1 deficiency affects synapse formation remain elusive. By mirroring human brain development with cerebral organoids, WFS...

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Detalles Bibliográficos
Autores principales: Yuan, Fei, Li, Yana, Hu, Rui, Gong, Mengting, Chai, Mengyao, Ma, Xuefei, Cha, Jiaxue, Guo, Pan, Yang, Kaijiang, Li, Mushan, Xu, Minglu, Ma, Qing, Su, Qiang, Zhang, Chuan, Sheng, Zhejin, Wu, Heng, Wang, Yuan, Yuan, Wen, Bian, Shan, Shao, Li, Zhang, Ru, Li, Kaicheng, Shao, Zhen, Zhang, Zhen-Ning, Li, Weida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208983/
https://www.ncbi.nlm.nih.gov/pubmed/36750736
http://dx.doi.org/10.1038/s41380-023-01987-3

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