The sphingolipids ceramide and inositol phosphorylceramide protect the Leishmania major membrane from sterol-specific toxins

The accessibility of sterols in mammalian cells to exogenous sterol-binding agents has been well-described previously, but sterol accessibility in distantly related protozoa is unclear. The human pathogen Leishmania major uses sterols and sphingolipids distinct from those used in mammals. Sterols in...

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Detalles Bibliográficos
Autores principales: Haram, Chaitanya S., Moitra, Samrat, Keane, Rilee, Kuhlmann, F. Matthew, Frankfater, Cheryl, Hsu, Fong-Fu, Beverley, Stephen M., Zhang, Kai, Keyel, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209034/
https://www.ncbi.nlm.nih.gov/pubmed/37094699
http://dx.doi.org/10.1016/j.jbc.2023.104745

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