Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

Maintaining mitochondrial function is critical to an improved healthspan and lifespan. Introducing mild stress by inhibiting mitochondrial translation invokes the mitochondrial unfolded protein response (UPR(mt)) and increases lifespan in several animal models. Notably, lower mitochondrial ribosomal...

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Detalles Bibliográficos
Autores principales: Reid, Kim, Daniels, Eileen G., Vasam, Goutham, Kamble, Rashmi, Janssens, Georges E., Hu, Iman M., Green, Alexander E., Houtkooper, Riekelt H., Menzies, Keir J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209074/
https://www.ncbi.nlm.nih.gov/pubmed/37225705
http://dx.doi.org/10.1038/s41598-023-35196-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209074/
https://www.ncbi.nlm.nih.gov/pubmed/37225705
http://dx.doi.org/10.1038/s41598-023-35196-3

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