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Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice
Maintaining mitochondrial function is critical to an improved healthspan and lifespan. Introducing mild stress by inhibiting mitochondrial translation invokes the mitochondrial unfolded protein response (UPR(mt)) and increases lifespan in several animal models. Notably, lower mitochondrial ribosomal...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209074/ https://www.ncbi.nlm.nih.gov/pubmed/37225705 http://dx.doi.org/10.1038/s41598-023-35196-3 |